Natural Products Targeting Mitochondria: Emerging Therapeutics for Age-associated Neurological Disorders

Overview

Journal Pharmacol Ther

Specialty Pharmacology

Date 2020 Nov 23

PMID 33227325

Citations 27

Authors

Zhibin Liang

Antonio Currais

David Soriano-Castell

David Schubert

Pamela Maher

Affiliations

Soon will be listed here.

Abstract

Mitochondria are the primary source of energy production in the brain thereby supporting most of its activity. However, mitochondria become inefficient and dysfunctional with age and to a greater extent in neurological disorders. Thus, mitochondria represent an emerging drug target for many age-associated neurological disorders. This review summarizes recent advances (covering from 2010 to May 2020) in the use of natural products from plant, animal, and microbial sources as potential neuroprotective agents to restore mitochondrial function. Natural products from diverse classes of chemical structures are discussed and organized according to their mechanism of action on mitochondria in terms of modulation of biogenesis, dynamics, bioenergetics, calcium homeostasis, and membrane potential, as well as inhibition of the oxytosis/ferroptosis pathway. This analysis emphasizes the significant value of natural products for mitochondrial pharmacology as well as the opportunities and challenges for the discovery and development of future neurotherapeutics.

Citing Articles

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