Latest Insights on ABO-incompatible Living-donor Renal Transplantation

Overview

Journal Int J Urol

Specialty Urology

Date 2019 Sep 16

PMID 31522462

Citations 8

Authors

Junji Uchida

Akihiro Kosoku

Toshihide Naganuma

Tomoaki Tanaka

Tatsuya Nakatani

Affiliations

Soon will be listed here.

Abstract

This review summarizes the latest insights on ABO-incompatible living-donor renal transplantation. Desensitization protocols and clinical outcomes were investigated, and a comparison was made with kidney-paired donation, which is not permitted in Japan for ethical reasons. Although renal transplantation is greatly beneficial for most patients with end-stage kidney disease, many of these patients must remain on dialysis therapy for extended periods due to the scarcity of organs from deceased donors. ABO blood type incompatibility was once believed to be a contraindication to renal transplantation due to the increased risk for antibody-mediated rejection and early graft loss attributable to isoagglutinins. Recently, pretransplant desensitization strategies, such as removal of isoagglutinins and antibody-producing cells, have achieved successful outcomes, although it remains unclear whether graft survival and patient morbidity are equivalent to those for ABO-compatible renal transplantation. The present review suggested that ABO-incompatible living-donor renal transplantation might be a favorable radical renal replacement therapy for patients with end-stage kidney disease.

Citing Articles

The Burden of ABO-Incompatible Kidney Transplantation: Readmission Rates and Complications, a Twenty-Year Analysis.

Berchtold C, Huebel K, Roessler F, Graf N, Dutkowski P, Lehmann K J Clin Med. 2024; 13(23).

PMID: 39685934 PMC: 11642097. DOI: 10.3390/jcm13237477.

Herpes zoster development in living kidney transplant recipients receiving low-dose rituximab.

Nishida H, Fukuhara H, Takai S, Nawano T, Takehara T, Narisawa T Int J Urol. 2024; 32(1):88-93.

PMID: 39373100 PMC: 11729987. DOI: 10.1111/iju.15600.

ABO-Incompatible Renal Transplant: A Single-Center Experience from India.

Pawar N, Tiwari V, Gupta A, Divyaveer S, Rather I, Chadha S Indian J Nephrol. 2024; 34(1):24-30.

PMID: 38645921 PMC: 11003606. DOI: 10.4103/ijn.ijn_247_22.

Incidence of postoperative cytomegalovirus and BK-polyoma virus infections and graft loss in ABO-incompatible renal transplant recipients: a multicenter retrospective study.

Kodama H, Hatakeyama S, Matsuura T, Saito M, Nishida H, Hamaya T Int Urol Nephrol. 2024; 56(7):2187-2193.

PMID: 38332424 DOI: 10.1007/s11255-023-03934-1.

Seroprevalence of SARS-CoV-2 spike IgG antibodies after the second BNT162b2 mRNA vaccine in Japanese kidney transplant recipients.

Hamaya T, Hatakeyama S, Yoneyama T, Tobisawa Y, Kodama H, Fujita T Sci Rep. 2022; 12(1):5876.

PMID: 35393481 PMC: 8988536. DOI: 10.1038/s41598-022-09897-0.

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