Identification of Factors Affecting Mortality in Late-Onset Ventilator-Associated Pneumonia

Overview

Journal Eurasian J Med

Publisher Aves

Specialty General Medicine

Date 2020 Nov 19

PMID 33209077

Citations 1

Authors

Aziz Ahmad Hamidi

Serhat Kescioglu

Affiliations

Soon will be listed here.

Abstract

Objective: Pneumonia that develops 48 hours after intubation has been defined as ventilator-associated pneumonia (VAP) in patients hospitalized in the intensive care unit (ICU). Late-onset VAP (LO-VAP) is described as pneumonia that occurs within or after the 5th day of mechanical ventilation. We aimed to determine the factors that affect the mortality and survival in patients with LO-VAP.

Materials And Methods: We retrospectively reviewed the hospital records of adult patients (>18 years) who developed LO-VAP in the training and research hospital between January 2014 and June 2018. We compared the demographic findings and laboratory characteristics of the survivors and deaths on the 28-day mortality.

Results: The mean age of 231 (90 female and 141 male) patients with LO-VAP was 73.43±14.06 years. As a result of multivariate logistic regression analysis, we determined that advanced age (p=0.023; 95% confidence interval [CI]: 1.003-1.047) and unconsciousness (p=0.001; 95% CI: 1.674-6.547) were the independent factors affecting mortality. However, parenteral nutrition (PN) (p=0.027; 95% CI: 0.263-0.923) and tracheostomy (p=0.001; 95% CI: 0.112-0.545) were the independent factors supporting survival. We found that acute physiology and chronic health evaluation II score, presence of bacteremia, and enteral nutrition did not have a significant effect on mortality.

Conclusion: Use of tracheostomy and PN in patients with LO-VAP has a positive effect on survival. Our study also points out that mortality can be high in patients with advanced age and unconsciousness.

Citing Articles

Clinical Outcomes of Early vs. Late Tracheostomy in Ventilated COVID-19 Patients.

Alkoheji H, Alabbasi L, Aldoseri M, Abdulrahman Yusuf K, Nasser M, Alkhan J Cureus. 2024; 16(7):e63757.

PMID: 39100001 PMC: 11296702. DOI: 10.7759/cureus.63757.

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