Prognostic Risk Factors in Ventilator-Associated Pneumonia

Overview

Journal Med Sci Monit

Specialties General Medicine
Pathology

Date 2018 Mar 6

PMID 29503436

Citations 22

Authors

Ziyaattin Karakuzu

Remzi Iscimen

Halis Akalin

Nermin Kelebek Girgin

Ferda Kahveci

Melda Sinirtas

Affiliations

Soon will be listed here.

Abstract

BACKGROUND Ventilator-associated pneumonia (VAP) is a nosocomial infection commonly seen in patients in intensive care units (ICU). This study aimed to analyze factors affecting prognosis of patients diagnosed with VAP. MATERIAL AND METHODS Critically ill patients with VAP were retrospectively evaluated between June 2002 and June 2011 in the ICU. VAP diagnosis was made according to 2005 ATS/IDSA (Infectious Diseases Society of America/American Thoracic Society) criteria. First pneumonia attacks of patients were analyzed. RESULTS When early- and late-onset pneumonia causes were compared according to ICU and hospital admittance, resistant bacteria were found to be more common in pneumonias classified as early-onset according to ICU admittance. APACHE II score of >21 (p=0.016), SOFA score of >6 (p<0.001) on admission to ICU and SOFA score of >6 (p<0.001) on day of diagnosis are risk factors affecting mortality. Additionally, low PaO2/FIO2 ratio at onset of VAP had a negative effect on prognosis (p<0.001). SOFA score of >6 on the day of VAP diagnosis was an independent risk factor for mortality [(p<0.001; OR (95%CI): 1.4 (1.2-1.6)]. CONCLUSIONS Resistant bacteria might be present in early-onset VAP. Especially, taking LOS into consideration may better estimate the presence of resistant bacteria. Acinetobacter baumannii, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus (MRSA) were the most frequent causative microorganisms for VAP. SOFA score might be more valuable than APACHE II score. Frequently surveilling SOFA scores may improve predictive performance over time.

Citing Articles

Ventilator-Associated Pneumonia After Cardiac Arrest and Prevention Strategies: A Narrative Review.

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PMID: 39859060 PMC: 11767168. DOI: 10.3390/medicina61010078.

Exploring Ventilator-Associated Pneumonia: Microbial Clues and Biomarker Insights from a Retrospective Study.

Gouda A, Sileem A, Elnahas H, Tawfik A, Eid R, Shati A Medicina (Kaunas). 2024; 60(8).

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Elhabashy S, Moriyama M, Mahmoud E, Eysa B BMC Nurs. 2024; 23(1):225.

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Immediate vs. culture-initiated antibiotic therapy in suspected non-severe ventilator-associated pneumonia: a before-after study (DELAVAP).

Martin M, Forveille S, Lascarrou J, Seguin A, Canet E, Lemarie J Ann Intensive Care. 2024; 14(1):33.

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