Frontiers in Non-union Research

Overview

Journal EFORT Open Rev

Specialty Orthopedics

Date 2020 Nov 18

PMID 33204499

Citations 12

Authors

Enrique Gomez-Barrena

Norma G Padilla-Eguiluz

Philippe Rosset

Affiliations

Soon will be listed here.

Abstract

Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing.Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products.Basic science and research on non-union treatments is needed to compile preclinical data on new treatments.Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment.Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products. Cite this article: 2020;5:574-583. DOI: 10.1302/2058-5241.5.190062.

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