Adaptation of the Carbamoyl-phosphate Synthetase Enzyme in an Extremophile Fish

Overview

Journal R Soc Open Sci

Specialty Science

Date 2020 Nov 18

PMID 33204476

Citations 5

Authors

Lewis J White

Gemma Sutton

Asilatu Shechonge

Julia J Day

Kanchon K Dasmahapatra

Mary E Pownall

Affiliations

Soon will be listed here.

Abstract

Tetrapods and fish have adapted distinct carbamoyl-phosphate synthase (CPS) enzymes to initiate the ornithine urea cycle during the detoxification of nitrogenous wastes. We report evidence that in the ureotelic subgenus of extremophile fish , CPS III has undergone convergent evolution and adapted its substrate affinity to ammonia, which is typical of terrestrial vertebrate CPS I. Unusually, unlike in other vertebrates, the expression of CPS III in is localized to the skeletal muscle and is activated in the myogenic lineage during early embryonic development with expression remaining in mature fish. We propose that adaptation in included both convergent evolution of CPS function to that of terrestrial vertebrates, as well as changes in development mechanisms redirecting gene expression to the skeletal muscle.

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