Clinical Profile of -Associated Uveitis in an Egyptian Cohort

Overview

Journal Clin Ophthalmol

Publisher Dove Medical Press

Specialty Ophthalmology

Date 2020 Nov 18

PMID 33204062

Citations 1

Authors

Eiman Abd El Latif

Ahmed Shawkat Abdelhalim

Affiliations

Soon will be listed here.

Abstract

Purpose: To describe the clinical profile of patients with HLA-B27-associated uveitis at 2 Egyptian tertiary eye centers.

Methods: A retrospective study reviewing the medical records of all patients with HLA-B27-associated uveitis served at 2 uveitis referral clinics in Egypt between January 2010 and June 2018.

Results: The study included a total of 554 patients. Anterior uveitis was the most common type. Ankylosing spondylitis was an important systemic comorbidity in the present study, affecting 27.4% of our patients. Cataract was the most frequent ocular complication. By the conclusion of the study, 6.1% of the affected eyes had a BSCVA poorer than 20/200.

Conclusion: The clinical profile of HLA-B27-associated uveitis in our cohort of Egyptian patients is similar to that reported from other regions of the world. In our study, a relatively high rate of cataract was observed.

Citing Articles

Clinical characterization of patients with HLA-B27-associated uveitis and evaluation of the impact of systemic treatment on the recurrence rate: a cross-sectional study.

Pineda-Sierra J, Cifuentes-Gonzalez C, Rojas-Carabali W, Munoz-Vargas P, Henao-Posada A, de-la-Torre A J Ophthalmic Inflamm Infect. 2023; 13(1):38.

PMID: 37646883 PMC: 10468442. DOI: 10.1186/s12348-023-00352-3.

References

Jabs D, Nussenblatt R, Rosenbaum J . Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005; 140(3):509-16. PMC: 8935739. DOI: 10.1016/j.ajo.2005.03.057. View

Pascual E, Fontanilla Ortega P, Vicens Bernabeu E, Martinez-Costa L, Blanco Alonso R . Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis. Reumatol Clin. 2015; 12(5):244-7. DOI: 10.1016/j.reuma.2015.11.008. View

Ruby A, Jampol L . Crohn's disease and retinal vascular disease. Am J Ophthalmol. 1990; 110(4):349-53. DOI: 10.1016/s0002-9394(14)77013-8. View

Bawazeer A, Joharjy H . The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study. Clin Ophthalmol. 2013; 7:2107-11. PMC: 3817032. DOI: 10.2147/OPTH.S53518. View

Rodriguez A, Akova Y, Pedroza-Seres M, Foster C . Posterior segment ocular manifestations in patients with HLA-B27-associated uveitis. Ophthalmology. 1994; 101(7):1267-74. DOI: 10.1016/s0161-6420(94)31179-1. View

Duker J, Brown G, Brooks L . Retinal vasculitis in Crohn's disease. Am J Ophthalmol. 1987; 103(5):664-8. DOI: 10.1016/s0002-9394(14)74326-0. View

Sanghvi C, Mercieca K, Jones N . Very severe HLA B27-associated panuveitis mimicking endophthalmitis: a case series. Ocul Immunol Inflamm. 2010; 18(2):139-41. DOI: 10.3109/09273940903560236. View

Tuominen J, Saari K . Uveitis survey at the University Eye Clinic in Turku. Acta Ophthalmol (Copenh). 1994; 72(4):505-12. DOI: 10.1111/j.1755-3768.1994.tb02805.x. View

Braakenburg A, Rothova A . The clinical characteristics of retinal vasculitis in HLA-B27-positive patients. Ocul Immunol Inflamm. 2013; 22(3):197-202. DOI: 10.3109/09273948.2013.835429. View

10.

Nizamuddin S, Bawazeer A . Causes of uveitis in a tertiary center in Western Saudi Arabia. Saudi Med J. 2013; 34(4):379-87. View

11.

Lange C, Feltgen N, Junker B, Schulze-Bonsel K, Bach M . Resolving the clinical acuity categories "hand motion" and "counting fingers" using the Freiburg Visual Acuity Test (FrACT). Graefes Arch Clin Exp Ophthalmol. 2008; 247(1):137-42. DOI: 10.1007/s00417-008-0926-0. View

12.

Roe R, Castelo Branco B, Cunningham Jr E . Hypotony maculopathy in a patient with HLA-B27-associated uveitis. Ocul Immunol Inflamm. 2008; 16(3):107-8. DOI: 10.1080/09273940802023794. View

13.

Pathanapitoon K, Suksomboon S, Kunavisarut P, Ausayakhun S, Wattananikorn S, Leetrakool N . HLA-B27-associated acute anterior uveitis in the University Referral Centre in North Thailand: clinical presentation and visual prognosis. Br J Ophthalmol. 2006; 90(12):1448-50. PMC: 1857526. DOI: 10.1136/bjo.2006.099788. View

14.

Chang J, McCluskey P, Wakefield D . Acute anterior uveitis and HLA-B27. Surv Ophthalmol. 2005; 50(4):364-88. DOI: 10.1016/j.survophthal.2005.04.003. View

15.

Al Dhahri H, Al Rubaie K, Hemachandran S, Mousa A, Gikandi P, Al-Mezaine H . Patterns of Uveitis in a University-based Tertiary Referral Center in Riyadh, Saudi Arabia. Ocul Immunol Inflamm. 2014; 23(4):311-319. DOI: 10.3109/09273948.2014.939197. View

16.

McCannel C, Holland G, Helm C, Cornell P, Winston J, Rimmer T . Causes of uveitis in the general practice of ophthalmology. UCLA Community-Based Uveitis Study Group. Am J Ophthalmol. 1996; 121(1):35-46. DOI: 10.1016/s0002-9394(14)70532-x. View

17.

DAmbrosio E, La Cava M, Tortorella P, Gharbiya M, Campanella M, Iannetti L . Clinical Features and Complications of the HLA-B27-associated Acute Anterior Uveitis: A Metanalysis. Semin Ophthalmol. 2016; 32(6):689-701. DOI: 10.3109/08820538.2016.1170158. View

18.

Chang J, Wakefield D . Uveitis: a global perspective. Ocul Immunol Inflamm. 2003; 10(4):263-79. DOI: 10.1076/ocii.10.4.263.15592. View

19.

Park S, Ham D . Clinical features and prognosis of HLA-B27 positive and negative anterior uveitis in a Korean population. J Korean Med Sci. 2009; 24(4):722-8. PMC: 2719208. DOI: 10.3346/jkms.2009.24.4.722. View

20.

Abd El Latif E, Ammar H . Uveitis Referral Pattern in Upper and Lower Egypt. Ocul Immunol Inflamm. 2018; 27(6):875-882. DOI: 10.1080/09273948.2017.1410183. View