Resident Memory T Cells and Their Role Within the Liver

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Nov 18

PMID 33202970

Citations 6

Authors

Sonia Ghilas

Ana-Maria Valencia-Hernandez

Matthias H Enders

William R Heath

Daniel Fernandez-Ruiz

Affiliations

Soon will be listed here.

Abstract

Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses-the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and distributions within the body. They can be broadly separated into circulating memory cells, which pace the entire body through the lymphatics and blood, and tissue-resident memory T (T) cells, which are constrained to peripheral tissues. Retained in the tissues where they form, T cells provide a frontline defense against reinfection. Here, we review this population of cells with specific attention to the liver, where T cells have been found to protect against infections, in particular those by species that cause malaria.

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