Reduced Antioxidant Response of the Fan Mussel Related to the Presence of

Overview

Journal Pathogens

Date 2020 Nov 14

PMID 33187065

Citations 8

Authors

Antonio Box

Xavier Capo

Silvia Tejada

Gaetano Catanese

Amalia Grau

Salud Deudero

Antoni Sureda

Jose Maria Valencia

Affiliations

Soon will be listed here.

Abstract

The endemic fan mussel () in the Mediterranean Sea is at high risk of disappearance due to massive mortality events. The aim of the study was to evaluate the antioxidant response of collected in the Balearic Islands (Western Mediterranean) before and after the mass mortality event. Individuals collected before (between 2011 and 2012) and after (between 2016 and 2017) the event were analyzed by histological, molecular, and biochemical methods to compare pathogenic loads and biochemical responses. All the individuals collected during 2016-2017 presented symptoms of the disease and were positive for , while acid-fast bacteria or/and Gram-negative bacteria were detected in some individuals of both sampling periods. The activities of the antioxidant enzymes catalase and superoxide dismutase in the gills were significantly lower in affected with the parasite compared to those in the asymptomatic ones, while levels of malondialdehyde, as an indicator of lipid peroxidation, were higher in infected individuals. When analyzing the differential effects of and sp. on , it was observed that significant effects on biomarkers were only observed in the presence of . Co-infection of by with other pathogens such as sp. constitutes a serious problem due to its high mortality rate in the Balearic Island waters. This concerning situation for is favored by a reduction in antioxidant defenses related to infection that induces oxidative stress and cell damage.

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