Mitochondrial Miro GTPases Coordinate Mitochondrial and Peroxisomal Dynamics

Overview

Journal Small GTPases

Specialties Biochemistry
Cell Biology

Date 2020 Nov 13

PMID 33183150

Citations 10

Authors

Konrad E Zinsmaier

Affiliations

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Abstract

Mitochondria and peroxisomes are highly dynamic, multifunctional organelles. Both perform key roles for cellular physiology and homoeostasis by mediating bioenergetics, biosynthesis, and/or signalling. To support cellular function, they must be properly distributed, of proper size, and be able to interact with other organelles. Accumulating evidence suggests that the small atypical GTPase Miro provides a central signalling node to coordinate mitochondrial as well as peroxisomal dynamics. In this review, I summarize our current understanding of Miro-dependent functions and molecular mechanisms underlying the proper distribution, size and function of mitochondria and peroxisomes.

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