DISC1 Genetics, Biology and Psychiatric Illness

Overview

Journal Front Biol (Beijing)

Specialty Biology

Date 2013 Apr 4

PMID 23550053

Citations 54

Authors

Pippa A Thomson

Elise L V Malavasi

Ellen Grunewald

Dinesh C Soares

Malgorzata Borkowska

J Kirsty Millar

Affiliations

Soon will be listed here.

Abstract

Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.

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References

Burdick K, Kamiya A, Hodgkinson C, Lencz T, DeRosse P, Ishizuka K . Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet. 2008; 17(16):2462-73. PMC: 2486442. DOI: 10.1093/hmg/ddn146. View

Mata I, Perez-Iglesias R, Roiz-Santianez R, Tordesillas-Gutierrez D, Gonzalez-Mandly A, Berja A . Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia. Neuroimage. 2009; 53(3):1016-22. DOI: 10.1016/j.neuroimage.2009.11.010. View

Han X, Tomizawa K, Fujimura A, Ohmori I, Nishiki T, Matsushita M . Regulation of mitochondrial dynamics and neurodegenerative diseases. Acta Med Okayama. 2011; 65(1):1-10. DOI: 10.18926/AMO/43824. View

Kubo K, Tomita K, Uto A, Kuroda K, Seshadri S, Cohen J . Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi. Biochem Biophys Res Commun. 2010; 400(4):631-7. PMC: 2949544. DOI: 10.1016/j.bbrc.2010.08.117. View

Thomson P, Harris S, Starr J, Whalley L, Porteous D, Deary I . Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neurosci Lett. 2005; 389(1):41-5. DOI: 10.1016/j.neulet.2005.07.004. View

Park Y, Jeong J, Lee H, Mun J, Kim J, Lee J . Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A. 2010; 107(41):17785-90. PMC: 2955093. DOI: 10.1073/pnas.1004361107. View

Li Y, Liu B, Hou B, Qin W, Wang D, Yu C . Less efficient information transfer in Cys-allele carriers of DISC1: a brain network study based on diffusion MRI. Cereb Cortex. 2012; 23(7):1715-23. DOI: 10.1093/cercor/bhs167. View

AlKhaja A, Jans D, Nikolov M, Vukotic M, Lytovchenko O, Ludewig F . MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Mol Biol Cell. 2011; 23(2):247-57. PMC: 3258170. DOI: 10.1091/mbc.E11-09-0774. View

Kristiansen L, Huerta I, Beneyto M, Meador-Woodruff J . NMDA receptors and schizophrenia. Curr Opin Pharmacol. 2006; 7(1):48-55. DOI: 10.1016/j.coph.2006.08.013. View

10.

Namba T, Ming G, Song H, Waga C, Enomoto A, Kaibuchi K . NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1). J Neurochem. 2011; 118(1):34-44. PMC: 4142346. DOI: 10.1111/j.1471-4159.2011.07282.x. View

11.

Lipina T, Kaidanovich-Beilin O, Patel S, Wang M, Clapcote S, Liu F . Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3. Synapse. 2010; 65(3):234-48. PMC: 4485461. DOI: 10.1002/syn.20839. View

12.

Karpinski B, Morle G, Huggenvik J, Uhler M, Leiden J . Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. Proc Natl Acad Sci U S A. 1992; 89(11):4820-4. PMC: 49179. DOI: 10.1073/pnas.89.11.4820. View

13.

Louvi A, Grove E . Cilia in the CNS: the quiet organelle claims center stage. Neuron. 2011; 69(6):1046-60. PMC: 3070490. DOI: 10.1016/j.neuron.2011.03.002. View

14.

Lipina T, Wang M, Liu F, Roder J . Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice. Neuropharmacology. 2011; 62(3):1252-62. DOI: 10.1016/j.neuropharm.2011.02.020. View

15.

Beecham G, Martin E, Li Y, Slifer M, Gilbert J, Haines J . Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet. 2009; 84(1):35-43. PMC: 2668056. DOI: 10.1016/j.ajhg.2008.12.008. View

16.

Fujita T, Maturana A, Ikuta J, Hamada J, Walchli S, Suzuki T . Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Biochem Biophys Res Commun. 2007; 361(3):605-10. DOI: 10.1016/j.bbrc.2007.07.050. View

17.

Sawamura N, Sawamura-Yamamoto T, Ozeki Y, Ross C, Sawa A . A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc Natl Acad Sci U S A. 2005; 102(4):1187-92. PMC: 545838. DOI: 10.1073/pnas.0406543102. View

18.

Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A . DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry. 2008; 14(9):865-73. DOI: 10.1038/mp.2008.22. View

19.

Ameri K, Harris A . Activating transcription factor 4. Int J Biochem Cell Biol. 2007; 40(1):14-21. DOI: 10.1016/j.biocel.2007.01.020. View

20.

Lemos D, Goodspeed L, Tonelli L, Antoch M, Ojeda S, Urbanski H . Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock. Endocrinology. 2007; 148(12):5811-21. DOI: 10.1210/en.2007-0610. View