Ketamine and Calcium Signaling-A Crosstalk for Neuronal Physiology and Pathology

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Nov 13

PMID 33182497

Citations 11

Authors

Malwina Lisek

Ludmila Zylinska

Tomasz Boczek

Affiliations

Soon will be listed here.

Abstract

Ketamine is a non-competitive antagonist of NMDA (N-methyl-D-aspartate) receptor, which has been in clinical practice for over a half century. Despite recent data suggesting its harmful side effects, such as neuronal loss, synapse dysfunction or disturbed neural network formation, the drug is still applied in veterinary medicine and specialist anesthesia. Several lines of evidence indicate that structural and functional abnormalities in the nervous system caused by ketamine are crosslinked with the imbalanced activity of multiple Ca-regulated signaling pathways. Due to its ubiquitous nature, Ca is also frequently located in the center of ketamine action, although the precise mechanisms underlying drug's negative or therapeutic properties remain mysterious for the large part. This review seeks to delineate the relationship between ketamine-triggered imbalance in Ca homeostasis and functional consequences for downstream processes regulating key aspects of neuronal function.

Citing Articles

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