The Prognostic and Predictive Value of Tumor Infiltrating Macrophage and Neutrophil in Patient with Clear Cell Renal Cell Carcinoma: Tumor Infiltrating Lymphocytes in Renal Cell Carcinoma

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Nov 12

PMID 33181696

Citations 11

Authors

Weiqiang Xu

Xu Jiang

Chao Guan

Mingli Gu

Affiliations

Soon will be listed here.

Abstract

Renal cell carcinoma (RCC) is the leading cancer affecting humans; however, the relationship between tumour-infiltrating lymphocytes (TILs) and patient prognosis in RCC is relatively unreported. This study aimed to investigate the relationships among factors (TIL, clinicopathological characteristics, and patient prognosis in RCC).This retrospective study evaluated 533 patients with clear cell renal cell carcinoma (ccRCC) deposited in the the Cancer Genome Atlas between 2004 and 2015. We downloaded immune cell type absolute fraction data for ccRCC patients from the Cancer Immunome Atlas database. The CIBERSORT method was used to transform RNA-sequencing data into microarray data for the cancer genome atlas -ccRCC samples for which microarray and RNA-sequencing data were available on the the Cancer Immunome Atlas website.The overall survival (OS) and disease free survival (DFS) analyses of ccRCC patients showed that M1 macrophages (OS, P = .00000134; DFS, P = .00958) and neutrophils (OS, P = .00000723; DFS, P = .0255) were significant. Age at diagnosis (P < .0001, c-index = 0.59), tumour stage (P < .0001, c-index = 0.667), stage (P < .0001, c-index = 0.729), neoplasm histological grade (P < .0001, c-index = 0.624), and haemoglobin level (P < .0001, c-index = 0.583) were independent predictors of OS. Similarly, the stage, haemoglobin level, and serum calcium level were independent predictors of DFS. There were significant correlations between the M1 macrophage fraction and tumour stage, stage, and neoplasm histological grade. Stage and neoplasm histological grade showed associations with the neutrophil fraction.The correlations between TILs and prognosis and clinicopathological characteristics in ccRCC were demonstrated. The prognosis of ccRCC patients may differ according to the TIL fractions.

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References

Papale M, Vocino G, Lucarelli G, Rutigliano M, Gigante M, Rocchetti M . Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma. Oncotarget. 2017; 8(25):40412-40424. PMC: 5522321. DOI: 10.18632/oncotarget.16341. View

Neofytou K, Smyth E, Giakoustidis A, Khan A, Cunningham D, Mudan S . Elevated platelet to lymphocyte ratio predicts poor prognosis after hepatectomy for liver-only colorectal metastases, and it is superior to neutrophil to lymphocyte ratio as an adverse prognostic factor. Med Oncol. 2014; 31(10):239. DOI: 10.1007/s12032-014-0239-6. View

Ray-Coquard I, Cropet C, Van Glabbeke M, Sebban C, Cesne A, Judson I . Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res. 2009; 69(13):5383-91. PMC: 2775079. DOI: 10.1158/0008-5472.CAN-08-3845. View

Condeelis J, Pollard J . Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006; 124(2):263-6. DOI: 10.1016/j.cell.2006.01.007. View

Dannenmann S, Thielicke J, Stockli M, Matter C, von Boehmer L, Cecconi V . Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma. Oncoimmunology. 2013; 2(3):e23562. PMC: 3655740. DOI: 10.4161/onci.23562. View

Ownby H, Roi L, Isenberg R, Brennan M . Peripheral lymphocyte and eosinophil counts as indicators of prognosis in primary breast cancer. Cancer. 1983; 52(1):126-30. DOI: 10.1002/1097-0142(19830701)52:1<126::aid-cncr2820520123>3.0.co;2-y. View

Taylor R, Patel A, Panageas K, Busam K, Brady M . Tumor-infiltrating lymphocytes predict sentinel lymph node positivity in patients with cutaneous melanoma. J Clin Oncol. 2007; 25(7):869-75. DOI: 10.1200/JCO.2006.08.9755. View

Rashid F, Waraich N, Bhatti I, Saha S, Khan R, Ahmed J . A pre-operative elevated neutrophil: lymphocyte ratio does not predict survival from oesophageal cancer resection. World J Surg Oncol. 2010; 8:1. PMC: 2819243. DOI: 10.1186/1477-7819-8-1. View

Lamb G, McMillan D, Ramsey S, Aitchison M . The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer. Br J Cancer. 2006; 94(6):781-4. PMC: 3216422. DOI: 10.1038/sj.bjc.6603034. View

10.

Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D . Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade. Cell Rep. 2017; 18(1):248-262. DOI: 10.1016/j.celrep.2016.12.019. View

11.

Ni X, Zhang X, Ou-Yang Q, Qian G, Wang L, Chen S . An elevated peripheral blood lymphocyte-to-monocyte ratio predicts favorable response and prognosis in locally advanced breast cancer following neoadjuvant chemotherapy. PLoS One. 2014; 9(11):e111886. PMC: 4221197. DOI: 10.1371/journal.pone.0111886. View

12.

Siegel R, Miller K, Jemal A . Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67(1):7-30. DOI: 10.3322/caac.21387. View

13.

LORD B, Bronchud M, Owens S, Chang J, Howell A, Souza L . The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo. Proc Natl Acad Sci U S A. 1989; 86(23):9499-503. PMC: 298524. DOI: 10.1073/pnas.86.23.9499. View

14.

Steidl C, Lee T, Shah S, Farinha P, Han G, Nayar T . Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N Engl J Med. 2010; 362(10):875-85. PMC: 2897174. DOI: 10.1056/NEJMoa0905680. View

15.

Takeuchi H, Kawanaka H, Fukuyama S, Kubo N, Hiroshige S, Yano T . Comparison of the prognostic values of preoperative inflammation-based parameters in patients with breast cancer. PLoS One. 2017; 12(5):e0177137. PMC: 5425200. DOI: 10.1371/journal.pone.0177137. View

16.

Ceze N, Thibault G, Goujon G, Viguier J, Watier H, Dorval E . Pre-treatment lymphopenia as a prognostic biomarker in colorectal cancer patients receiving chemotherapy. Cancer Chemother Pharmacol. 2011; 68(5):1305-13. DOI: 10.1007/s00280-011-1610-3. View

17.

Gigante M, Lucarelli G, Divella C, Netti G, Pontrelli P, Cafiero C . Soluble Serum αKlotho Is a Potential Predictive Marker of Disease Progression in Clear Cell Renal Cell Carcinoma. Medicine (Baltimore). 2015; 94(45):e1917. PMC: 4912252. DOI: 10.1097/MD.0000000000001917. View

18.

Lee K, Kim E, Yun J, Park Y, DO S, Chae S . The prognostic and predictive value of tumor-infiltrating lymphocytes and hematologic parameters in patients with breast cancer. BMC Cancer. 2018; 18(1):938. PMC: 6167816. DOI: 10.1186/s12885-018-4832-5. View

19.

Lucarelli G, Loizzo D, Franzin R, Battaglia S, Ferro M, Cantiello F . Metabolomic insights into pathophysiological mechanisms and biomarker discovery in clear cell renal cell carcinoma. Expert Rev Mol Diagn. 2019; 19(5):397-407. DOI: 10.1080/14737159.2019.1607729. View

20.

Tamma R, Rutigliano M, Lucarelli G, Annese T, Ruggieri S, Cascardi E . Microvascular density, macrophages, and mast cells in human clear cell renal carcinoma with and without bevacizumab treatment. Urol Oncol. 2019; 37(6):355.e11-355.e19. DOI: 10.1016/j.urolonc.2019.01.025. View