Stem Cell-based Therapies for Fertility Preservation in Males: Current Status and Future Prospects
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With the decline in male fertility in recent years, strategies for male fertility preservation have received increasing attention. In this study, by reviewing current treatments and recent publications, we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation, focusing on the use of spermatogonial stem cells (SSCs), SSC niches, SSC-based testicular organoids, other stem cell types such as mesenchymal stem cells, and stem cell-derived extracellular vesicles. In conclusion, a more comprehensive understanding of the germ cell microenvironment, stem cell-derived extracellular vesicles, and testicular organoids will play an important role in achieving male fertility preservation.
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Zhao S, Li Z, Li K, Dai X, Xu Z, Li L Cell Transplant. 2024; 33:9636897231219395.
PMID: 38173262 PMC: 10768580. DOI: 10.1177/09636897231219395.
A brief history of testicular organoids: from theory to the wards.
Nengzhuang W, Jiaming S, Minghua L, Long M, Lina Q, Xuemei G J Assist Reprod Genet. 2022; 39(7):1423-1431.
PMID: 35653042 PMC: 9365919. DOI: 10.1007/s10815-022-02529-6.
Qamar A, Hussain T, Rafique M, Bang S, Tanga B, Seong G Cells. 2021; 10(9).
PMID: 34572109 PMC: 8468931. DOI: 10.3390/cells10092460.
Regulation of Cell Types Within Testicular Organoids.
Martins Lara N, Sakib S, Dobrinski I Endocrinology. 2021; 162(4).
PMID: 33570577 PMC: 7901658. DOI: 10.1210/endocr/bqab033.