Role of Adipokines in Systemic Sclerosis Pathogenesis

Overview

Journal Eur J Rheumatol

Publisher Aves

Specialty Rheumatology

Date 2020 Nov 9

PMID 33164731

Citations 5

Authors

Klaus W Frommer

Elena Neumann

Ulf Muller-Ladner

Affiliations

Soon will be listed here.

Abstract

Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease with manifestations in multiple organs, including the skin, lung, heart, joints, gastrointestinal tract, kidney, and liver. Its pathophysiology is characterized by inflammation, fibrosis, and vascular damage, with an increased expression of numerous cytokines, chemokines, and growth factors. However, besides these growth factors and cytokines, another group of molecules may be involved in the pathogenesis of SSc: the adipokines. Adipokines are proteins with metabolic and cytokine-like properties, which were originally found to be expressed by adipose tissue. However, their expression is not limited to this tissue, and they can also be found in other organs. Therefore, this review will describe the current knowledge regarding adipokines in the context of SSc and try to elucidate their potential role in the pathogenesis of SSc.

Citing Articles

In the Pursuit of Metabolic Markers of Systemic Sclerosis-Plasma Adiponectin and Omentin-1 in Monitoring the Course of the Disease.

Dopytalska K, Kalisz M, Litwiniuk A, Walecka I, Bik W, Baranowska-Bik A Int J Mol Sci. 2023; 24(12).

PMID: 37373131 PMC: 10298489. DOI: 10.3390/ijms24129988.

Higher body mass index is associated with a lower iloprost infusion rate tolerance and higher iloprost-related adverse events in patients with systemic sclerosis.

Bixio R, Adami G, Bertoldo E, Giollo A, Morciano A, Bertelle D Ther Adv Musculoskelet Dis. 2022; 14:1759720X221137125.

PMID: 36439640 PMC: 9685102. DOI: 10.1177/1759720X221137125.

Adiponectin: a pleiotropic hormone with multifaceted roles.

Shklyaev S, Melnichenko G, Volevodz N, Falaleeva N, Ivanov S, Kaprin A Probl Endokrinol (Mosk). 2022; 67(6):98-112.

PMID: 35018766 PMC: 9753852. DOI: 10.14341/probl12827.

Serum resistin is predictive marker of development of new digital ulcers in systemic sclerosis.

Pellicano C, Leodori G, Colalillo A, Navarini L, Gigante A, Rosato E Clin Exp Med. 2021; 22(3):421-426.

PMID: 34462844 PMC: 9338111. DOI: 10.1007/s10238-021-00756-2.

A special European Journal of Rheumatology issue on systemic sclerosis: What and why?.

Del Galdo F, Matucci-Cerinic M Eur J Rheumatol. 2020; 7(Suppl 3):S137-S138.

PMID: 33164730 PMC: 7647686. DOI: 10.5152/eurjrheum.2020.090121.

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