Adiponectin: a Pleiotropic Hormone with Multifaceted Roles

Overview

Journal Probl Endokrinol (Mosk)

Specialty Endocrinology

Date 2022 Jan 12

PMID 35018766

Authors

S S Shklyaev

G A Melnichenko

N N Volevodz

N A Falaleeva

S A Ivanov

A D Kaprin

N G Mokrysheva

Affiliations

Soon will be listed here.

Abstract

Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologically active factors known as adipokines. The most abundant of them is adiponectin. This adipocite-derived hormone exerts pleiotropic actions and exhibits insulin-sensitizing, antidiabetic, anti-obesogenic, anti-inflammatory, antiatherogenic, cardio- and neuroprotective properties. Contrariwise to its protective effects against various pathological events in different cell types, adiponectin may have links to several systemic diseases and malignances. Reduction in adiponectin levels has an implication in COVID-19-associated respiratory failure, which is attributed mainly to a phenomenon called 'adiponectin paradox'. Ample evidence about multiple functions of adiponectin in the body was obtained from animal, mostly rodent studies. Our succinct review is entirely about multifaceted roles of adiponectin and mechanisms of its action in different physiological and pathological states.

Citing Articles

Acute phase proteins patterns as biomarkers in bacterial infection: Recent insights.

Al Ali A, Darwish W Open Vet J. 2024; 14(10):2539-2550.

PMID: 39545194 PMC: 11560262. DOI: 10.5455/OVJ.2024.v14.i10.4.

High-Fat Diet Augments Myocardial Inflammation and Cardiac Dysfunction in Arrhythmogenic Cardiomyopathy.

Centner A, Shiel E, Farra W, Cannon E, Landim-Vieira M, Salazar G Nutrients. 2024; 16(13).

PMID: 38999835 PMC: 11243382. DOI: 10.3390/nu16132087.

Serum adiponectin and peroxisome proliferator-activated receptors-γ levels in obese patients with and without prediabetes.

Gul M, Tozcu D, Tekcan A, Capraz M, Dortok Demir H Rev Assoc Med Bras (1992). 2024; 70(3):e20231000.

PMID: 38655997 PMC: 11045203. DOI: 10.1590/1806-9282.20231000.

Reevaluating Adiponectin's impact on obesity hypertension: a Chinese case-control study.

Wu O, Lu X, Leng J, Zhang X, Liu W, Yang F BMC Cardiovasc Disord. 2024; 24(1):208.

PMID: 38615012 PMC: 11015577. DOI: 10.1186/s12872-024-03865-4.

The association between adipokines and pulmonary diseases: a mendelian randomization study.

Wu D, Wang Z, Wang K, Wang Y, Wang T BMC Pulm Med. 2024; 24(1):50.

PMID: 38263093 PMC: 10804699. DOI: 10.1186/s12890-024-02863-8.

References

Ishikawa M, Kitayama J, Kazama S, Hiramatsu T, Hatano K, Nagawa H . Plasma adiponectin and gastric cancer. Clin Cancer Res. 2005; 11(2 Pt 1):466-72. View

Saito I, Yamagishi K, Chei C, Cui R, Ohira T, Kitamura A . Total and high molecular weight adiponectin levels and risk of cardiovascular disease in individuals with high blood glucose levels. Atherosclerosis. 2013; 229(1):222-7. DOI: 10.1016/j.atherosclerosis.2013.04.014. View

Markaki A, Psylinakis E, Spyridaki A . Adiponectin and end-stage renal disease. Hormones (Athens). 2016; 15(3):345-354. DOI: 10.14310/horm.2002.1698. View

Shibata R, Ouchi N, Murohara T . Adiponectin and cardiovascular disease. Circ J. 2009; 73(4):608-14. DOI: 10.1253/circj.cj-09-0057. View

Christou G, Kiortsis D . The role of adiponectin in renal physiology and development of albuminuria. J Endocrinol. 2014; 221(2):R49-61. DOI: 10.1530/JOE-13-0578. View

Chandran M, Phillips S, Ciaraldi T, Henry R . Adiponectin: more than just another fat cell hormone?. Diabetes Care. 2003; 26(8):2442-50. DOI: 10.2337/diacare.26.8.2442. View

Pereira R, Snell-Bergeon J, Erickson C, Schauer I, Bergman B, Rewers M . Adiponectin dysregulation and insulin resistance in type 1 diabetes. J Clin Endocrinol Metab. 2012; 97(4):E642-7. PMC: 3319187. DOI: 10.1210/jc.2011-2542. View

Xu A, Chan K, Hoo R, Wang Y, Tan K, Zhang J . Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem. 2005; 280(18):18073-80. DOI: 10.1074/jbc.M414231200. View

Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J . Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999; 257(1):79-83. DOI: 10.1006/bbrc.1999.0255. View

10.

Hotamisligil G . Inflammation and metabolic disorders. Nature. 2006; 444(7121):860-7. DOI: 10.1038/nature05485. View

11.

Wang Y, Lam K, Xu J, Lu G, Xu L, Cooper G . Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem. 2005; 280(18):18341-7. DOI: 10.1074/jbc.M501149200. View

12.

Cannon B, Nedergaard J . Cell biology: Neither brown nor white. Nature. 2012; 488(7411):286-7. DOI: 10.1038/488286a. View

13.

Petridou E, Mantzoros C, Dessypris N, Koukoulomatis P, Addy C, Voulgaris Z . Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece. J Clin Endocrinol Metab. 2003; 88(3):993-7. DOI: 10.1210/jc.2002-021209. View

14.

Halberg N, Schraw T, Wang Z, Kim J, Yi J, Hamilton M . Systemic fate of the adipocyte-derived factor adiponectin. Diabetes. 2009; 58(9):1961-70. PMC: 2731534. DOI: 10.2337/db08-1750. View

15.

Kim K, Baek A, Hwang J, Choi Y, Jeong J, Lee M . Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation. Cancer Res. 2009; 69(9):4018-26. DOI: 10.1158/0008-5472.CAN-08-2641. View

16.

Goto M, Goto A, Morita A, Deura K, Sasaki S, Aiba N . Low-molecular-weight adiponectin and high-molecular-weight adiponectin levels in relation to diabetes. Obesity (Silver Spring). 2013; 22(2):401-7. DOI: 10.1002/oby.20553. View

17.

Blaak E . Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care. 2001; 4(6):499-502. DOI: 10.1097/00075197-200111000-00006. View

18.

Luo Y, Lin H . Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease. Immun Inflamm Dis. 2020; 9(1):59-73. PMC: 7860600. DOI: 10.1002/iid3.391. View

19.

Miyazaki T, Bub J, Uzuki M, Iwamoto Y . Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3. Biochem Biophys Res Commun. 2005; 333(1):79-87. DOI: 10.1016/j.bbrc.2005.05.076. View

20.

Recinella L, Orlando G, Ferrante C, Chiavaroli A, Brunetti L, Leone S . Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases. Front Physiol. 2020; 11:578966. PMC: 7662468. DOI: 10.3389/fphys.2020.578966. View