Two New Compounds from a Mangrove Sediment-derived Fungus H175

Two new compounds, 6-acetyl-4-methoxy-3,5-dimethyl-2-pyran-2-one () and (2,4)-5-((2,3,4,5)-3,4-dihydroxy-2,4,5-trimethyltetrahydrofuran-2-yl)-2,4-dimethylpenta-2,4-dienal (), and 22 known compounds were identified from the mangrove-forest-derived fungus H175. The structures of these compounds were elucidated by analysis of the high-resolution electrospray ionisation mass spectroscopy (HR-ESI-MS), 1 D and 2 D nuclear magnetic resonance (NMR) data. The hypoglycaemic effect of compounds was evaluated by the Tg (Ins: htBidTE-ON; LR) zebrafish model. Compound (aspterric acid) exhibited a significant hypoglycaemic effect equivalent to the positive drug rosiglitazone (RSG) at 10 μmol/L.