An Observational Study on Ca Supplementation and Dietary Intake During Pregnancy on Low Birth Weight and Small for Gestational Age

Overview

Journal Public Health Nutr

Publisher Cambridge University Press

Date 2020 Nov 4

PMID 33143813

Citations 1

Authors

Wei Dai

Xiaohui Deng

Lanlan Li

Jie Qiu

Baohong Mao

Yawen Shao

Sijuan Xu

Tao Yang

Xiaochun He

Hongmei Cui

Xiaojuan Lin

Ling Lv

Zhongfeng Tang

Qing Liu

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the effects of dietary Ca intake and Ca supplementation during pregnancy on low birth weight (LBW) and small for gestational age (SGA) infants.

Design: A birth cohort study was conducted in 2010-2012 at the Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China.

Setting: A birth cohort study.

Participants: Totally, 9595 pregnant women who came to the hospital for delivery at 20 weeks of gestation or more, and who were 18 years of age or older.

Results: Compared with non-users, Ca supplement users had a reduced risk of LBW infants (OR = 0·77, 95 % CI: 0·63, 0·95) and a reduced risk of nulliparous women giving birth to LBW infants (OR = 0·75, 95 % CI: 0·58, 0·98) (P < 0·05). More specifically, both the use of Ca supplement before conception and during pregnancy (OR = 0·44, 95 % CI: 0·19, 0·99) and during pregnancy only (OR = 0·80, 95 % CI: 0·65, 0·99) had the main effect of reducing risk of nulliparous women giving birth to LBW infants (P < 0·05). There was no association between Ca supplementation and SGA (OR = 0·87, 95 % CI: 0·75, 1·01) (P > 0·05). However, higher dietary Ca intake during pregnancy decreases the risk of both LBW (quartile 2: OR = 0·72, 95 % CI: 0·55, 0·94; quartile 3: OR = 0·68, 95 % CI: 0·50, 0·62) and SGA infants (quartile 2: OR = 0·77, 95 % CI: 0·63, 0·95; quartile 3: OR = 0·71, 95 % CI: 0·57, 0·88, quartile 4: OR = 0·71, 95 % CI: 0·57, 0·88) (P < 0·05).

Conclusions: Ca supplementation and adequate dietary intake of Ca during pregnancy are associated with a decreased risk of LBW infants born to nulliparous women.

Citing Articles

Low serum lipase levels in mothers of children with stunted growth indicate the possibility of low calcium absorption during pregnancy: A cross-sectional study in North Sumatra, Indonesia.

Sari D, Amelia R, Masyithah D, Tantrakarnapa K PLoS One. 2024; 19(6):e0298253.

PMID: 38843179 PMC: 11156305. DOI: 10.1371/journal.pone.0298253.

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