Modeling Neurodevelopment in a Dish with Pluripotent Stem Cells

Overview

Journal Dev Growth Differ

Specialties Biology
Reproductive Medicine

Date 2020 Nov 3

PMID 33141454

Citations 9

Authors

Kent Imaizumi

Hideyuki Okano

Affiliations

Soon will be listed here.

Abstract

Pluripotent stem cells (PSCs) can differentiate into all cell types in the body, and their differentiation procedures recapitulate the developmental processes of embryogenesis. Focusing on neurodevelopment, we describe here the application of knowledge gained from embryology to the neural induction of PSCs. Furthermore, PSC-based neural modeling provides novel insights into neurodevelopmental processes. In particular, human PSC cultures are a powerful tool for the study of human-specific neurodevelopmental processes and could even enable the elucidation of the mechanisms of human brain evolution. We also discuss challenges and potential future directions in further improving PSC-based neural modeling.

Citing Articles

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