LncRNA-mediated Posttranslational Modifications and Reprogramming of Energy Metabolism in Cancer

Overview

Journal Cancer Commun (Lond)

Publisher Wiley

Specialty Oncology

Date 2020 Oct 29

PMID 33119215

Citations 272

Authors

Yue-Tao Tan

Jin-Fei Lin

Ting Li

Jia-Jun Li

Rui-Hua Xu

Huai-Qiang Ju

Affiliations

Soon will be listed here.

Abstract

Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors. It is well recognized that long noncoding RNAs (lncRNAs) regulate energy metabolism in cancer. However, lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at present. In this review, we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes, transcription factors, and other proteins involved in metabolic pathways. In addition, we discuss the mechanisms through which these interactions contribute to tumor initiation and progression, and the key roles and clinical significance of functional lncRNAs. We believe that an in-depth understanding of lncRNA-mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.

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