The Path to Cancer --Three Strikes and You're Out

Overview

Journal N Engl J Med

Specialty General Medicine

Date 2015 Nov 13

PMID 26559569

Citations 137

Authors

Bert Vogelstein

Kenneth W Kinzler

Affiliations

Soon will be listed here.

Abstract

Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults, alterations in as few as three driver genes appear to suffice for a cell to evolve into an advanced cancer.

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