Broadening and Enhancing Bacteriocins Activities by Association with Bioactive Substances

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2020 Oct 29

PMID 33114656

Citations 11

Authors

Hassan Zgheib

Djamel Drider

Yanath Belguesmia

Affiliations

Soon will be listed here.

Abstract

Bacteriocins are antimicrobial peptides some of which are endowed with antiviral, anticancer and antibiofilm properties. These properties could be improved through synergistic interactions of these bacteriocins with other bioactive molecules such as antibiotics, phages, nanoparticles and essential oils. A number of studies are steadily reporting the effects of these combinations as new and potential therapeutic strategies in the future, as they may offer many incentives over existing therapies. In particular, bacteriocins can benefit from combination with nanoparticles which can improve their stability and solubility, and protect them from enzymatic degradation, reduce their interactions with other molecules and improve their bioavailability. Furthermore, the combination of bacteriocins with other antimicrobials is foreseen as a way to reduce the development of antibiotic resistance due to the involvement of several modes of action. Another relevant advantage of these synergistic combinations is that it decreases the concentration of each antimicrobial component, thereby reducing their side effects such as their toxicity. In addition, combination can extend the utility of bacteriocins as antiviral or anticancer agents. Thus, in this review, we report and discuss the synergistic effects of bacteriocin combinations as medicines, and also for other diverse applications including, antiviral, antispoilage, anticancer and antibiofilms.

Citing Articles

Synthesis, Characterization, and Biomedical Applications of Bacteriocin-Selenium Nanoconjugates.

Al-Shimmary S, Al-Thwani A Probiotics Antimicrob Proteins. 2024; .

PMID: 39658757 DOI: 10.1007/s12602-024-10420-2.

Biopreservation of Food Using Bacteriocins From Lactic Acid Bacteria: Classification, Mechanisms, and Commercial Applications.

Putri D, Lei J, Rossiana N, Syaputri Y Int J Microbiol. 2024; 2024:8723968.

PMID: 39641100 PMC: 11620799. DOI: 10.1155/ijm/8723968.

Optimization of culture conditions for endophytic bacteria in mangrove plants and isolation and identification of bacteriocin.

Peng J, Xie X, Fan T, Ma H, Li Y, Luo S Front Pharmacol. 2024; 15:1429423.

PMID: 39156104 PMC: 11327053. DOI: 10.3389/fphar.2024.1429423.

Pharmacological composition based on bacteriocinnisin in experiments and .

Isakova M, Oparina O, Belousov A, Lysova Y Open Vet J. 2024; 14(6):1370-1383.

PMID: 39055763 PMC: 11268911. DOI: 10.5455/OVJ.2024.v14.i6.5.

Suppression of planktonic and biofilm of Escherichia coli by the synergistic lantibiotics-polymyxins combinations.

Polyudova T, Lemkina L, Eroshenko D, Esaev A Arch Microbiol. 2024; 206(4):191.

PMID: 38520490 DOI: 10.1007/s00203-024-03922-8.

References

Line J, Svetoch E, Eruslanov B, Perelygin V, Mitsevich E, Mitsevich I . Isolation and purification of enterocin E-760 with broad antimicrobial activity against gram-positive and gram-negative bacteria. Antimicrob Agents Chemother. 2007; 52(3):1094-100. PMC: 2258513. DOI: 10.1128/AAC.01569-06. View

Ali A, Ahmed S . A review on chitosan and its nanocomposites in drug delivery. Int J Biol Macromol. 2017; 109:273-286. DOI: 10.1016/j.ijbiomac.2017.12.078. View

Klaenhammer T . Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol Rev. 1993; 12(1-3):39-85. DOI: 10.1111/j.1574-6976.1993.tb00012.x. View

Ladjouzi R, Lucau-Danila A, Benachour A, Drider D . A Leaderless Two-Peptide Bacteriocin, Enterocin DD14, Is Involved in Its Own Self-Immunity: Evidence and Insights. Front Bioeng Biotechnol. 2020; 8:644. PMC: 7332713. DOI: 10.3389/fbioe.2020.00644. View

Kwizera E, Chaffin E, Shen X, Chen J, Zou Q, Wu Z . Size- and Shape-Controlled Synthesis and Properties of Magnetic-Plasmonic Core-Shell Nanoparticles. J Phys Chem C Nanomater Interfaces. 2016; 120(19):10530-10546. PMC: 4882128. DOI: 10.1021/acs.jpcc.6b00875. View

Chikindas M, Weeks R, Drider D, Chistyakov V, Dicks L . Functions and emerging applications of bacteriocins. Curr Opin Biotechnol. 2017; 49:23-28. PMC: 5799035. DOI: 10.1016/j.copbio.2017.07.011. View

Balto H, Shakoor Z, Kanfar M . Combined effect of a mixture of tetracycline, acid, and detergent, and nisin against Enterococcus faecalis and Actinomyces viscosus biofilms. Saudi Med J. 2015; 36(2):211-5. PMC: 4375700. DOI: 10.15537/smj.2015.2.9947. View

Angelopoulou A, Field D, Perez-Ibarreche M, Warda A, Hill C, Ross R . Vancomycin and nisin A are effective against biofilms of multi-drug resistant Staphylococcus aureus isolates from human milk. PLoS One. 2020; 15(5):e0233284. PMC: 7259672. DOI: 10.1371/journal.pone.0233284. View

Naghmouchi K, Drider D, Baah J, Teather R . Nisin A and Polymyxin B as Synergistic Inhibitors of Gram-positive and Gram-negative Bacteria. Probiotics Antimicrob Proteins. 2016; 2(2):98-103. DOI: 10.1007/s12602-009-9033-8. View

10.

Malaczewska J, Kaczorek-Lukowska E, Wojcik R, Siwicki A . Antiviral effects of nisin, lysozyme, lactoferrin and their mixtures against bovine viral diarrhoea virus. BMC Vet Res. 2019; 15(1):318. PMC: 6727482. DOI: 10.1186/s12917-019-2067-6. View

11.

Naghmouchi K, Belguesmia Y, Baah J, Teather R, Drider D . Antibacterial activity of class I and IIa bacteriocins combined with polymyxin E against resistant variants of Listeria monocytogenes and Escherichia coli. Res Microbiol. 2010; 162(2):99-107. DOI: 10.1016/j.resmic.2010.09.014. View

12.

Drider D, Bendali F, Naghmouchi K, Chikindas M . Bacteriocins: Not Only Antibacterial Agents. Probiotics Antimicrob Proteins. 2016; 8(4):177-182. DOI: 10.1007/s12602-016-9223-0. View

13.

Naveen S, Kalaivani K . Cancer stem cells and evolving novel therapies: a paradigm shift. Stem Cell Investig. 2018; 5:4. PMC: 5803031. DOI: 10.21037/sci.2018.01.03. View

14.

Kaur S, Kaur S . Bacteriocins as Potential Anticancer Agents. Front Pharmacol. 2015; 6:272. PMC: 4639596. DOI: 10.3389/fphar.2015.00272. View

15.

Messaoudi S, Kergourlay G, Dalgalarrondo M, Choiset Y, Ferchichi M, Prevost H . Purification and characterization of a new bacteriocin active against Campylobacter produced by Lactobacillus salivarius SMXD51. Food Microbiol. 2012; 32(1):129-34. DOI: 10.1016/j.fm.2012.05.002. View

16.

Firenzuoli F, Jaitak V, Horvath G, Bassole I, Setzer W, Gori L . Essential oils: new perspectives in human health and wellness. Evid Based Complement Alternat Med. 2014; 2014:467363. PMC: 4090492. DOI: 10.1155/2014/467363. View

17.

Kitazaki K, Koga S, Nagatoshi K, Kuwano K, Zendo T, Nakayama J . In vitro synergistic activities of cefazolin and nisin A against mastitis pathogens. J Vet Med Sci. 2017; 79(9):1472-1479. PMC: 5627315. DOI: 10.1292/jvms.17-0180. View

18.

Iseppi R, Camellini S, Sabia C, Messi P . Combined antimicrobial use of essential oils and bacteriocin bacLP17 as seafood biopreservative to control Listeria monocytogenes both in planktonic and in sessile forms. Res Microbiol. 2020; 171(8):351-356. DOI: 10.1016/j.resmic.2020.07.002. View

19.

Flores-Mireles A, Walker J, Caparon M, Hultgren S . Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015; 13(5):269-84. PMC: 4457377. DOI: 10.1038/nrmicro3432. View

20.

Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A . Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival. PLoS One. 2015; 10(7):e0131008. PMC: 4489501. DOI: 10.1371/journal.pone.0131008. View