Regulation of Ca Exchanges and Signaling in Mitochondria

Overview

Journal Curr Opin Physiol

Date 2020 Oct 26

PMID 33103015

Citations 10

Authors

Edmund J Carvalho

Peter B Stathopulos

Muniswamy Madesh

Affiliations

Soon will be listed here.

Abstract

Mitochondrial calcium (Ca) homeostasis also plays a key role in the buffering of cytosolic calcium (Ca) and calcium transported into the mitochondrial matrix regulates cellular metabolism, migration and cell fate decisions. Recent work has highlighted the importance of mCa homeostasis in regulating cellular function. The discovery of the mCa uptake complex has shed new light on the role of Ca dynamics in cytoskeletal remodeling, mitochondrial shape and motility in cellular dynamics. Here we attempt to decipher the vast landscape of calcium regulatory effects of the mitochondria, the underlying mechanisms and the dynamics that control cellular function.

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