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Is the Shielding Effect of Cholecalciferol in SARS CoV-2 Infection Dependable? An Evidence Based Unraveling

Overview
Specialty Public Health
Date 2020 Oct 26
PMID 33102933
Citations 1
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Abstract

Despite being announced as a global health concern and emergency in January by WHO, designing specific treatment for SARS-CoV-2 is still a summit yet to be conquered. Currently, many drugs are being tested in the clinical scenario and vitamins play a significant role in therapeutic management. Based on the available evidence, we postulate that maintaining normal vitamin D levels may reduce severity, mortality risk of COVID-19. This review elucidates the alarming need for randomized clinical trials to determine the role of vitamin D in patient prognosis in COVID-19 infection and on latitude bases epidemiological outcome.

Citing Articles

Relationship between Vitamin D and Immunity in Older People with COVID-19.

Lauretani F, Salvi M, Zucchini I, Testa C, Cattabiani C, Arisi A Int J Environ Res Public Health. 2023; 20(8).

PMID: 37107714 PMC: 10138672. DOI: 10.3390/ijerph20085432.

References
1.
Choudhary N, Gupta P . Vitamin D supplementation for severe pneumonia--a randomized controlled trial. Indian Pediatr. 2011; 49(6):449-54. DOI: 10.1007/s13312-012-0073-x. View

2.
Guan W, Ni Z, Hu Y, Liang W, Ou C, He J . Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; 382(18):1708-1720. PMC: 7092819. DOI: 10.1056/NEJMoa2002032. View

3.
Gray K, Wood N, Gunasekera H, Sheikh M, Hazelton B, Barzi F . Vitamin d and tuberculosis status in refugee children. Pediatr Infect Dis J. 2011; 31(5):521-3. DOI: 10.1097/INF.0b013e3182456c55. View

4.
Heaney R, Davies K, Chen T, Holick M, Barger-Lux M . Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2002; 77(1):204-10. DOI: 10.1093/ajcn/77.1.204. View

5.
Cai Q, Chen F, Wang T, Luo F, Liu X, Wu Q . Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China. Diabetes Care. 2020; 43(7):1392-1398. DOI: 10.2337/dc20-0576. View