Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation

Overview

Journal Nutrients

Date 2020 Oct 23

PMID 33092271

Citations 31

Authors

Kerstin Durholz

Jorg Hofmann

Aida Iljazovic

Julian Hager

Sebastien Lucas

Kerstin Sarter

Till Strowig

Holger Bang

Jurgen Rech

Georg Schett

Mario M Zaiss

Affiliations

Soon will be listed here.

Abstract

Chronic inflammatory diseases are often initiated and guided by the release of proinflammatory mediators. Rheumatoid arthritis (RA) is caused by an imbalance between the pro- and anti-inflammatory mediators in the joints, thereby favoring chronic inflammation and joint damage. Here, we investigate if short-term high-fiber dietary intervention shifts this towards anti-inflammatory mediators. Healthy controls ( = 10) and RA patients ( = 29) under routine care received daily high-fiber bars for 15 or 30 days, respectively. Stool and sera were analyzed for pro- and anti-inflammatory mediators. A high-fiber dietary intervention resulted in increased anti-inflammatory short-chain fatty acids (SCFA), decreased proarthritic cytokine concentrations, along with a durable shift in the Firmicutes-to-Bacteroidetes ratio. Together, these results further strengthen high-fiber dietary interventions as a practical approach complementing existing pharmacological therapies.

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