MYC in Brain Development and Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Oct 23

PMID 33092025

Citations 18

Authors

Olga Zaytseva

Nan-Hee Kim

Leonie M Quinn

Affiliations

Soon will be listed here.

Abstract

The MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance of stem cells. Not surprisingly, given MYC's capacity to promote programs of proliferative cell growth, MYC is frequently upregulated in cancer. Although members of the MYC family are upregulated in nervous system tumours, the mechanisms of how elevated MYC promotes stem cell-driven brain cancers is unknown. If we are to determine how increased MYC might contribute to brain cancer progression, we will require a more complete understanding of MYC's roles during normal brain development. Here, we evaluate evidence for MYC family functions in neural stem cell fate and brain development, with a view to better understand mechanisms of MYC-driven neural malignancies.

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References

Yoon K, Gaiano N . Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat Neurosci. 2005; 8(6):709-15. DOI: 10.1038/nn1475. View

Zindy F, Knoepfler P, Xie S, Sherr C, Eisenman R, Roussel M . N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A. 2006; 103(31):11579-83. PMC: 1518798. DOI: 10.1073/pnas.0604727103. View

Weathers S, Gilbert M . Toward Personalized Targeted Therapeutics: An Overview. Neurotherapeutics. 2016; 14(2):256-264. PMC: 5398979. DOI: 10.1007/s13311-016-0496-5. View

Quinn L, Secombe J, Hime G . Myc in stem cell behaviour: insights from Drosophila. Adv Exp Med Biol. 2013; 786:269-85. DOI: 10.1007/978-94-007-6621-1_15. View

Knoblich J . Asymmetric cell division: recent developments and their implications for tumour biology. Nat Rev Mol Cell Biol. 2010; 11(12):849-60. PMC: 3941022. DOI: 10.1038/nrm3010. View

Stanton B, Perkins A, Tessarollo L, Sassoon D, Parada L . Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev. 1992; 6(12A):2235-47. DOI: 10.1101/gad.6.12a.2235. View

Bhaduri A, Di Lullo E, Jung D, Muller S, Crouch E, Espinosa C . Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020; 26(1):48-63.e6. PMC: 7029801. DOI: 10.1016/j.stem.2019.11.015. View

Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W . c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell. 2012; 151(1):68-79. PMC: 3471363. DOI: 10.1016/j.cell.2012.08.033. View

Mirzoyan Z, Sollazzo M, Allocca M, Valenza A, Grifoni D, Bellosta P . : A Model Organism to Study Cancer. Front Genet. 2019; 10:51. PMC: 6405444. DOI: 10.3389/fgene.2019.00051. View

10.

Couturier C, Ayyadhury S, Le P, Nadaf J, Monlong J, Riva G . Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy. Nat Commun. 2020; 11(1):3406. PMC: 7343844. DOI: 10.1038/s41467-020-17186-5. View

11.

Rust K, Tiwari M, Mishra V, Grawe F, Wodarz A . Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in . EMBO J. 2018; 37(16). PMC: 6092623. DOI: 10.15252/embj.201798659. View

12.

Grandori C, Cowley S, James L, Eisenman R . The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol. 2000; 16:653-99. DOI: 10.1146/annurev.cellbio.16.1.653. View

13.

Araki R, Hoki Y, Uda M, Nakamura M, Jincho Y, Tamura C . Crucial role of c-Myc in the generation of induced pluripotent stem cells. Stem Cells. 2011; 29(9):1362-70. DOI: 10.1002/stem.685. View

14.

Orian A, Grewal S, Knoepfler P, Edgar B, Parkhurst S, Eisenman R . Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors. Cold Spring Harb Symp Quant Biol. 2006; 70:299-307. DOI: 10.1101/sqb.2005.70.019. View

15.

Meyer N, Penn L . Reflecting on 25 years with MYC. Nat Rev Cancer. 2008; 8(12):976-90. DOI: 10.1038/nrc2231. View

16.

Homem C, Knoblich J . Drosophila neuroblasts: a model for stem cell biology. Development. 2012; 139(23):4297-310. DOI: 10.1242/dev.080515. View

17.

Zinin N, Adameyko I, Wilhelm M, Fritz N, Uhlen P, Ernfors P . MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division. EMBO Rep. 2014; 15(4):383-91. PMC: 3989669. DOI: 10.1002/embr.201337424. View

18.

Downs K, Martin G, Bishop J . Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo. Genes Dev. 1989; 3(6):860-9. DOI: 10.1101/gad.3.6.860. View

19.

DePinho R, Schreiber-Agus N, Alt F . myc family oncogenes in the development of normal and neoplastic cells. Adv Cancer Res. 1991; 57:1-46. DOI: 10.1016/s0065-230x(08)60994-x. View

20.

Betschinger J, Mechtler K, Knoblich J . Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell. 2006; 124(6):1241-53. DOI: 10.1016/j.cell.2006.01.038. View