Advanced Risk Stratification of Intermediate Risk Group in Pulmonary Arterial Hypertension

Overview

Journal Pulm Circ

Publisher Wiley

Specialty Pulmonary Medicine

Date 2020 Oct 22

PMID 33088480

Citations 12

Authors

Athiththan Yogeswaran

Manuel J Richter

Natascha Sommer

Hossein A Ghofrani

Werner Seeger

Khodr Tello

Henning Gall

Affiliations

Soon will be listed here.

Abstract

In 301 treatment-naïve patients with pulmonary arterial hypertension stratified by the European Society of Cardiology/European Respiratory Society risk score, further stratification of intermediate-risk patients based on six-minute walk distance and the tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio identified a subset with mortality rates comparable to low-risk patients.

Citing Articles

Risk stratification and treatment goals in pulmonary arterial hypertension.

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Prognostic Value of Serial Risk Stratification in Adult and Pediatric Pulmonary Arterial Hypertension: A Systematic Review.

Lokhorst C, van der Werf S, Berger R, Douwes J J Am Heart Assoc. 2024; 13(13):e034151.

PMID: 38904230 PMC: 11255703. DOI: 10.1161/JAHA.123.034151.

Comparison of Contemporary Risk Scores in All Groups of Pulmonary Hypertension: A Pulmonary Vascular Research Institute GoDeep Meta-Registry Analysis.

Yogeswaran A, Gall H, Funderich M, Wilkins M, Howard L, Kiely D Chest. 2024; 166(3):585-603.

PMID: 38508334 PMC: 11443244. DOI: 10.1016/j.chest.2024.03.018.

Novel Echocardiographic Measurements of Right Ventricular-Pulmonary Artery Coupling in Predicting the Prognosis of Precapillary Pulmonary Hypertension.

Topyla-Putowska W, Tomaszewski M, Wojtkowska A, Wysokinski A J Pers Med. 2023; 13(12).

PMID: 38138854 PMC: 10744346. DOI: 10.3390/jpm13121627.

Evaluation of the European Society of Cardiology/European Respiratory Society derived three- and four-strata risk stratification models in pulmonary arterial hypertension: introducing an internet-based risk stratification calculator.

Ahmed A, Ahmed S, Kempe D, Radegran G Eur Heart J Open. 2023; 3(2):oead012.

PMID: 36959867 PMC: 10027577. DOI: 10.1093/ehjopen/oead012.

References

Boucly A, Weatherald J, Savale L, Jais X, Cottin V, Prevot G . Risk assessment, prognosis and guideline implementation in pulmonary arterial hypertension. Eur Respir J. 2017; 50(2). DOI: 10.1183/13993003.00889-2017. View

Gall H, Felix J, Schneck F, Milger K, Sommer N, Voswinckel R . The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups. J Heart Lung Transplant. 2017; 36(9):957-967. DOI: 10.1016/j.healun.2017.02.016. View

Tello K, Axmann J, Ghofrani H, Naeije R, Narcin N, Rieth A . Relevance of the TAPSE/PASP ratio in pulmonary arterial hypertension. Int J Cardiol. 2018; 266:229-235. DOI: 10.1016/j.ijcard.2018.01.053. View

Pencina M, DAgostino Sr R, DAgostino Jr R, Vasan R . Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med. 2007; 27(2):157-72. DOI: 10.1002/sim.2929. View

Kylhammar D, Kjellstrom B, Hjalmarsson C, Jansson K, Nisell M, Soderberg S . A comprehensive risk stratification at early follow-up determines prognosis in pulmonary arterial hypertension. Eur Heart J. 2017; 39(47):4175-4181. DOI: 10.1093/eurheartj/ehx257. View

Oudiz R, Barst R, Hansen J, Sun X, Garofano R, Wu X . Cardiopulmonary exercise testing and six-minute walk correlations in pulmonary arterial hypertension. Am J Cardiol. 2005; 97(1):123-6. DOI: 10.1016/j.amjcard.2005.07.129. View

Harrell Jr F, Lee K, Mark D . Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996; 15(4):361-87. DOI: 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4. View

Hoeper M, Kramer T, Pan Z, Eichstaedt C, Spiesshoefer J, Benjamin N . Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model. Eur Respir J. 2017; 50(2). DOI: 10.1183/13993003.00740-2017. View

Tello K, Ghofrani H, Heinze C, Krueger K, Naeije R, Raubach C . A simple echocardiographic estimate of right ventricular-arterial coupling to assess severity and outcome in pulmonary hypertension on chronic lung disease. Eur Respir J. 2019; 54(3). DOI: 10.1183/13993003.02435-2018. View

10.

Konstantinides S, Meyer G, Becattini C, Bueno H, Geersing G, Harjola V . 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European.... Eur Respir J. 2019; 54(3). DOI: 10.1183/13993003.01647-2019. View

11.

Richter M, Peters D, Ghofrani H, Naeije R, Roller F, Sommer N . Evaluation and Prognostic Relevance of Right Ventricular-Arterial Coupling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2019; 201(1):116-119. DOI: 10.1164/rccm.201906-1195LE. View

12.

Forfia P, Fisher M, Mathai S, Housten-Harris T, Hemnes A, Borlaug B . Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med. 2006; 174(9):1034-41. DOI: 10.1164/rccm.200604-547OC. View

13.

Galie N, Hoeper M, Humbert M, Torbicki A, Vachiery J, Barbera J . Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the.... Eur Heart J. 2009; 30(20):2493-537. DOI: 10.1093/eurheartj/ehp297. View

14.

Delcroix M, Staehler G, Gall H, Grunig E, Held M, Halank M . Risk assessment in medically treated chronic thromboembolic pulmonary hypertension patients. Eur Respir J. 2018; 52(5). DOI: 10.1183/13993003.00248-2018. View

15.

Galie N, Humbert M, Vachiery J, Gibbs S, Lang I, Torbicki A . 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS):.... Eur Respir J. 2015; 46(4):903-75. DOI: 10.1183/13993003.01032-2015. View

16.

Yogeswaran A, Richter M, Sommer N, Ghofrani H, Seeger W, Gall H . Evaluation of pulmonary hypertension by right heart catheterisation: does timing matter?. Eur Respir J. 2020; 56(3). DOI: 10.1183/13993003.01892-2019. View

17.

Tello K, Wan J, Dalmer A, Vanderpool R, Ghofrani H, Naeije R . Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019; 12(9):e009047. PMC: 7099862. DOI: 10.1161/CIRCIMAGING.119.009047. View

18.

Olsson K, Richter M, Kamp J, Gall H, Heine A, Ghofrani H . Intravenous treprostinil as an add-on therapy in patients with pulmonary arterial hypertension. J Heart Lung Transplant. 2019; 38(7):748-756. DOI: 10.1016/j.healun.2019.05.002. View

19.

Miyamoto S, Nagaya N, Satoh T, Kyotani S, Sakamaki F, Fujita M . Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2000; 161(2 Pt 1):487-92. DOI: 10.1164/ajrccm.161.2.9906015. View

20.

Galie N, Channick R, Frantz R, Grunig E, Jing Z, Moiseeva O . Risk stratification and medical therapy of pulmonary arterial hypertension. Eur Respir J. 2018; 53(1). PMC: 6351343. DOI: 10.1183/13993003.01889-2018. View