Family History and Pelvic Organ Prolapse: a Systematic Review and Meta-analysis

Overview

Journal Int Urogynecol J

Publisher Springer

Specialties Gynecology & Obstetrics
Urology

Date 2020 Oct 21

PMID 33084962

Citations 8

Authors

Parisa Samimi

Sarah H Jones

Ayush Giri

Affiliations

Soon will be listed here.

Abstract

Introduction And Hypothesis: Numerous analytic observational studies assess family history as a risk factor for POP and report a wide range of associations. This review aims to systematically evaluate the role of family history of POP in relation to POP risk and its recurrence.

Methods: A review was performed of the PubMed/MEDLINE database with search criteria specifying family history, risk factors, POP, and their synonyms as title/abstract keywords, as well as MESH terms, up to March 2020. We aggregated evidence across studies with fixed effects (FE) and random effects (RE) meta-analysis.

Results: Forty-three articles underwent full-text review. Eighteen independent studies evaluating the relationship between family history of POP and POP risk in 3639 POP cases and 10,912 controls were eligible for meta-analysis. Four studies evaluating family history and POP recurrence in 224 recurrent cases and 400 non-recurrent cases were eligible for inclusion into another meta-analyses. A positive family history of POP is on average associated with 2.3- to 2.7-fold increased risk for POP (RE OR = 2.64; 95% CI = 2.07, 3.35) as well as a 1.4-fold increased risk for POP recurrence (FE OR = 1.44; 95% CI = 1.00, 2.08). Meta-analysis estimates of POP risk varied by study design, definition of family history, and model adjustment status. We found evidence that publication bias and recall bias are a possibility.

Conclusions: Family history of POP is a risk factor for both POP presence and recurrence. However, reported magnitudes may be overestimates due to confounding, recall bias, and publication bias.

Citing Articles

Family history and acquired risk factors for pelvic organ prolapse: a case-control study in Japan.

Ashikari A, Kadekawa K, Tokushige A, Iwata H, Nagamine S, Machida N Sci Rep. 2025; 15(1):5717.

PMID: 39962132 PMC: 11832764. DOI: 10.1038/s41598-025-90202-0.

Genetic Etiology in Pelvic Organ Prolapse: Role of Connective Tissue Homeostasis, Hormone Metabolism, and Oxidative Stress.

Jiang W, Cheung R, Chung C, Chan S, Choy K Genes (Basel). 2025; 16(1).

PMID: 39858552 PMC: 11765207. DOI: 10.3390/genes16010005.

Unveiling the depths of pelvic organ prolapse: From risk factors to therapeutic methods (Review).

Gao J, Li Y, Hou J, Wang Y Exp Ther Med. 2024; 29(1):11.

PMID: 39582942 PMC: 11582525. DOI: 10.3892/etm.2024.12761.

Genetics of Female Pelvic Organ Prolapse: Up to Date.

Li Y, Li Z, Li Y, Gao X, Wang T, Huang Y Biomolecules. 2024; 14(9).

PMID: 39334862 PMC: 11430778. DOI: 10.3390/biom14091097.

Impact on Sexual Function and Wish for Subsequent Pregnancy after Uterus-Preserving Prolapse Surgery in Premenopausal Women.

Carlin G, Hummel Jimenez J, Lange S, Heinzl F, Koch M, Umek W J Clin Med. 2024; 13(14).

PMID: 39064144 PMC: 11277568. DOI: 10.3390/jcm13144105.

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