Genetics of Female Pelvic Organ Prolapse: Up to Date

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2024 Sep 28

PMID 39334862

Authors

Yuting Li

Zihan Li

Yinuo Li

Xiaofan Gao

Tian Wang

Yibao Huang

Mingfu Wu

Affiliations

Soon will be listed here.

Abstract

Pelvic organ prolapse (POP) is a benign disease characterized by the descent of pelvic organs due to weakened pelvic floor muscles and fascial tissues. Primarily affecting elderly women, POP can lead to various urinary and gastrointestinal tract symptoms, significantly impacting their quality of life. The pathogenesis of POP predominantly involves nerve-muscle damage and disorders in the extracellular matrix metabolism within the pelvic floor. Recent studies have indicated that genetic factors may play a crucial role in this condition. Focusing on linkage analyses, single-nucleotide polymorphisms, genome-wide association studies, and whole exome sequencing studies, this review consolidates current research on the genetic predisposition to POP. Advances in epigenetics are also summarized and highlighted, aiming to provide theoretical recommendations for risk assessments, diagnoses, and the personalized treatment for patients with POP.

Citing Articles

Risk prediction models for stress urinary incontinence after pelvic organ prolapse (POP) surgery: a systematic review and meta-analysis.

Yu B, He H, Wang L, Shao H, Liu Y, Yan X BMC Womens Health. 2025; 25(1):55.

PMID: 39923045 PMC: 11806609. DOI: 10.1186/s12905-025-03584-8.

Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets.

Chen Y, Ullah A, Chen W, Xuan J, Huang X, Liang S Mol Med. 2024; 30(1):214.

PMID: 39538179 PMC: 11562709. DOI: 10.1186/s10020-024-00989-3.

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