Bilateral Retrobulbar Optic Neuritis As the First Manifestation of Neuro-Behçet Disease

Overview

Journal Case Rep Rheumatol

Publisher Wiley

Date 2020 Oct 21

PMID 33083081

Citations 1

Authors

Mohsen Jari

Taiiebeh Mohammadi

Ensiyeh Taheri

Affiliations

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Abstract

Background: Behçet disease (BD) is a polygenic and chronic autoinflammatory multisystem vasculitis. Acute optic neuritis has been rarely reported in patients with BD, especially in children. . We reported an 8-year-old girl with a sudden visual loss and color vision impairment. The patient had a history of recurrent oral aphthous ulcers, genital ulcers, and chronic abdominal pain. On ophthalmic examination, anterior and posterior chambers and funduscopy of both eyes were normal. The results of laboratory tests for infectious and rheumatic diseases were normal. Brain magnetic resonance imaging and the result of cerebrospinal fluid analysis for oligoclonal bands and auto-antibodies were also normal. Pathergy skin test and human leukocyte antigens (HLA) B5 and HLA-B51 were positive. The patient was recognized as a case of BD-related bilateral retrobulbar optic neuritis and was treated by corticosteroids, azathioprine, colchicine, and infliximab.

Conclusion: Retrobulbar optic neuritis may be the first manifestation of neuro-BD.

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Xu J, Li H, Du X, Li J, Meng X, Huang C Front Immunol. 2021; 12:585412.

PMID: 34262554 PMC: 8273435. DOI: 10.3389/fimmu.2021.585412.

References

de Menthon M, LaValley M, Maldini C, Guillevin L, Mahr A . HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies. Arthritis Rheum. 2009; 61(10):1287-96. PMC: 3867978. DOI: 10.1002/art.24642. View

Krensky A, Grady S, Shanley K, BERENBERG W, Yunis E . Epidemic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome. Hum Immunol. 1983; 6(2):75-7. DOI: 10.1016/0198-8859(83)90063-0. View

Durrani K, Ahmed M, Foster C . Adamantiades-Behcet disease: diagnosis and current concepts in management of ocular manifestations. Compr Ophthalmol Update. 2007; 8(4):225-33. View

Jari M, Shiari R, Salehpour O, Rahmani K . Epidemiological and advanced therapeutic approaches to treatment of uveitis in pediatric rheumatic diseases: a systematic review and meta-analysis. Orphanet J Rare Dis. 2020; 15(1):41. PMC: 7001204. DOI: 10.1186/s13023-020-1324-x. View

Takeuchi M, Hokama H, Tsukahara R, Kezuka T, Goto H, Sakai J . Risk and prognostic factors of poor visual outcome in Behcet's disease with ocular involvement. Graefes Arch Clin Exp Ophthalmol. 2005; 243(11):1147-52. DOI: 10.1007/s00417-005-0005-8. View

McCluskey P, Powell R . The eye in systemic inflammatory diseases. Lancet. 2004; 364(9451):2125-33. DOI: 10.1016/S0140-6736(04)17554-5. View

Boomer J, Siatkowski R . Optic neuritis in adults and children. Semin Ophthalmol. 2004; 18(4):174-80. DOI: 10.1080/08820530390895172. View

Wang J, Tow S, Aung T, Lim S, Cullen J . The presentation, aetiology, management and outcome of optic neuritis in an Asian population. Clin Exp Ophthalmol. 2001; 29(5):312-5. DOI: 10.1046/j.1442-9071.2001.00442.x. View

. The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol. 2013; 28(3):338-47. DOI: 10.1111/jdv.12107. View

10.

Yilmazer M, Ozdemir R, Mese T, Kucuk M, Oner T, Devrim I . Kawasaki disease in Turkish children: a single center experience with emphasis on intravenous immunoglobulin resistance and giant coronary aneurysms. Turk J Pediatr. 2020; 61(5):648-656. DOI: 10.24953/turkjped.2019.05.002. View

11.

Pleyer U, Hazirolan D, Winterhalter S, Stubiger N . [Behçet's disease - ophthalmological and general aspects part I : etiology, pathogenesis and diagnostics]. Ophthalmologe. 2012; 109(11):1129-41. DOI: 10.1007/s00347-012-2698-5. View

12.

Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, Huseyin Altunbas H, Urgancioglu M . Uveitis in Behçet disease: an analysis of 880 patients. Am J Ophthalmol. 2004; 138(3):373-80. DOI: 10.1016/j.ajo.2004.03.022. View

13.

Kitaichi N, Miyazaki A, Iwata D, Ohno S, Stanford M, Chams H . Ocular features of Behcet's disease: an international collaborative study. Br J Ophthalmol. 2007; 91(12):1579-82. PMC: 2095523. DOI: 10.1136/bjo.2007.123554. View