[Behçet's Disease - Ophthalmological and General Aspects Part I : Etiology, Pathogenesis and Diagnostics]

Overview

Journal Ophthalmologe

Specialty Ophthalmology

Date 2012 Nov 27

PMID 23179819

Citations 5

Authors

U Pleyer

D Hazirolan

S Winterhalter

N Stubiger

Affiliations

Soon will be listed here.

Abstract

Behçet's disease (also known as morbus Behcet or Admantiades-Behcet syndrome) is a chronic vasculitis mainly characterized by recurrent mucocutaneous lesions and sight threatening uveitis. It may also involve joints, vessels of all sizes and the central nervous system. Because of its severe morbidity and considerable mortality early diagnosis and treatment is important. Treatment and prognosis of this disorder have profited considerably in recent years following the introduction of biologic agents. This article summarizes the current state of knowledge and emphasizes the important role of the ophthalmologist in the diagnosis and therapy of Behçet's disease.

Citing Articles

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Neuropsychiatric and behavioral profiles of 2 adults with williams syndrome: response to antidepressant intake.

Urgeles D, Alonso V, Ramos-Moreno T Prim Care Companion CNS Disord. 2014; 15(4).

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Behcet's disease: systemic and ocular manifestations.

Paovic J, Paovic P, Sredovic V Biomed Res Int. 2013; 2013:247345.

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Correlation between Ocular Manifestations and Their Complications as Opposed to Visual Acuity and Treatment in Behcet's Disease.

Paovic J, Paovic P, Sredovic V Autoimmune Dis. 2013; 2013:842673.

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[Behcet's disease--ophthalmological and general aspects: Part 2: Therapy].

Pleyer U, Hazirolan D, Winterhalter S, Stubiger N Ophthalmologe. 2013; 110(3):273-84.

PMID: 23504099 DOI: 10.1007/s00347-012-2780-z.

References

Deuter C, Kotter I, Wallace G, Murray P, Stubiger N, Zierhut M . Behçet's disease: ocular effects and treatment. Prog Retin Eye Res. 2007; 27(1):111-36. DOI: 10.1016/j.preteyeres.2007.09.002. View

Ozturk M, Ertenli I, Kiraz S, Haznedaroglu I, Celik I, Kirazli S . Plasminogen activator inhibitor-1 as a link between pathological fibrinolysis and arthritis of Behçet's disease. Rheumatol Int. 2003; 24(2):98-102. DOI: 10.1007/s00296-003-0324-1. View

Hazirolan D, Sungur G, Duman S . Demographic, clinical, and ocular features in patients with late-onset Behçet disease. Ocul Immunol Inflamm. 2012; 20(2):119-24. DOI: 10.3109/09273948.2012.655882. View

Altenburg A, Papoutsis N, Orawa H, Martus P, Krause L, Zouboulis C . [Epidemiology and clinical manifestations of Adamantiades-Behçet disease in Germany -- current pathogenetic concepts and therapeutic possibilities]. J Dtsch Dermatol Ges. 2006; 4(1):49-64. DOI: 10.1111/j.1610-0387.2006.05841.x. View

Chajek-Shaul T, Pisanty S, Knobler H, Matzner Y, Glick M, Ron N . HLA-B51 may serve as an immunogenetic marker for a subgroup of patients with Behçet's syndrome. Am J Med. 1987; 83(4):666-72. DOI: 10.1016/0002-9343(87)90896-5. View

Altenburg A, Mahr A, Maldini C, Kneifel C, Krause L, Kotter I . [Epidemiology and clinical aspects of Adamantiades-Behçet disease in Gemany. Current data]. Ophthalmologe. 2012; 109(6):531-41. DOI: 10.1007/s00347-012-2601-4. View

Ebert E . Gastrointestinal manifestations of Behçet's disease. Dig Dis Sci. 2008; 54(2):201-7. DOI: 10.1007/s10620-008-0337-4. View

Yoshida A, Kawashima H, Motoyama Y, Shibui H, Kaburaki T, Shimizu K . Comparison of patients with Behçet's disease in the 1980s and 1990s. Ophthalmology. 2004; 111(4):810-5. DOI: 10.1016/j.ophtha.2003.07.018. View

Mumcu G, Ergun T, Inanc N, Fresko I, Atalay T, Hayran O . Oral health is impaired in Behçet's disease and is associated with disease severity. Rheumatology (Oxford). 2004; 43(8):1028-33. DOI: 10.1093/rheumatology/keh236. View

10.

Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, Huseyin Altunbas H, Urgancioglu M . Uveitis in Behçet disease: an analysis of 880 patients. Am J Ophthalmol. 2004; 138(3):373-80. DOI: 10.1016/j.ajo.2004.03.022. View

11.

Shahram F, Davatchi F, Nadji A, Jamshidi A, Chams H, Chams C . Recent epidemiological data on Behçet's disease in Iran. The 2001 survey. Adv Exp Med Biol. 2003; 528:31-6. DOI: 10.1007/0-306-48382-3_5. View

12.

Verity D, Wallace G, Vaughan R, Kondeatis E, Madanat W, Zureikat H . HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behçet's disease. Tissue Antigens. 1999; 54(3):264-72. DOI: 10.1034/j.1399-0039.1999.540307.x. View

13.

Davatchi F, Chams-Davatchi C, Ghodsi Z, Shahram F, Nadji A, Shams H . Diagnostic value of pathergy test in Behcet's disease according to the change of incidence over the time. Clin Rheumatol. 2011; 30(9):1151-5. DOI: 10.1007/s10067-011-1694-5. View

14.

Mahr A, Belarbi L, Wechsler B, Jeanneret D, Dhote R, Fain O . Population-based prevalence study of Behçet's disease: differences by ethnic origin and low variation by age at immigration. Arthritis Rheum. 2008; 58(12):3951-9. DOI: 10.1002/art.24149. View

15.

Kaneko F, Togashi A, Saito S, Sakuma H, Oyama N, Nakamura K . Behçet's disease (Adamantiades-Behçet's disease). Clin Dev Immunol. 2010; 2011:681956. PMC: 2967828. DOI: 10.1155/2011/681956. View

16.

Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T . Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. Nat Genet. 2010; 42(8):703-6. DOI: 10.1038/ng.624. View

17.

Benezra D, Cohen E . Treatment and visual prognosis in Behçet's disease. Br J Ophthalmol. 1986; 70(8):589-92. PMC: 1040777. DOI: 10.1136/bjo.70.8.589. View

18.

Aydin E, Sogut S, Ozyurt H, Ozugurlu F, Akyol O . Comparison of serum nitric oxide, malondialdehyde levels, and antioxidant enzyme activities in Behçet's disease with and without ocular disease. Ophthalmic Res. 2004; 36(3):177-82. DOI: 10.1159/000077332. View

19.

Bang D, Oh S, Lee K, Lee E, Lee S . Influence of sex on patients with Behçet's disease in Korea. J Korean Med Sci. 2003; 18(2):231-5. PMC: 3055031. DOI: 10.3346/jkms.2003.18.2.231. View

20.

Direskeneli H . Autoimmunity vs autoinflammation in Behcet's disease: do we oversimplify a complex disorder?. Rheumatology (Oxford). 2006; 45(12):1461-5. DOI: 10.1093/rheumatology/kel329. View