Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features

Overview

Journal Case Rep Pathol

Publisher Wiley

Specialty Pathology

Date 2020 Oct 21

PMID 33083078

Citations 3

Authors

Karl Grenier

Gulbeyaz Altinel

Zari Dastani

Atilla Omeroglu

Affiliations

Soon will be listed here.

Abstract

Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes tumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit rhabdoid features, whether representing true differentiation or morphological mimic. We here report an epithelial-myoepithelial carcinoma of the breast with rhabdoid features in a 76-year-old woman. The rhabdoid-appearing myoepithelial cells are negative for myogenin, consistent with a rhabdoid-like morphology rather than a true rhabdoid differentiation, comparably to previously described myoepithelial carcinoma with rhabdoid features. To our knowledge, this is the first reported case of epithelial-myoepithelial carcinoma of the breast with rhabdoid features and thus adds another entity to the differential diagnosis of breast lesions with rhabdoid features.

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References

Ohtake H, Iwaba A, Kato T, Ohe R, Maeda K, Matsuda M . Myoepithelial carcinoma of the breast with focal rhabdoid features. Breast J. 2012; 19(1):100-3. DOI: 10.1111/tbj.12058. View

Skalova A, Weinreb I, Hyrcza M, Simpson R, Laco J, Agaimy A . Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. Am J Surg Pathol. 2015; 39(3):338-48. DOI: 10.1097/PAS.0000000000000364. View

Gandhi J, Mehta A, Gupta G, Sardana M . Malignant adenomyoepithelioma: a tumor of low malignant potential despite basal phenotype. Indian J Pathol Microbiol. 2011; 54(1):230-2. DOI: 10.4103/0377-4929.77421. View

Jones C, Tooze R, Lakhani S . Malignant adenomyoepithelioma of the breast metastasizing to the liver. Virchows Arch. 2003; 442(5):504-6. DOI: 10.1007/s00428-003-0806-2. View

Han B, Mori I, Nakamura M, Wang X, Ozaki T, Nakamura Y . Myoepithelial carcinoma arising in an adenomyoepithelioma of the breast: case report with immunohistochemical and mutational analysis. Pathol Int. 2006; 56(4):211-6. DOI: 10.1111/j.1440-1827.2006.01948.x. View

Baum J, Sung K, Tran H, Song W, Ginter P . Mammary Epithelial-Myoepithelial Carcinoma: Report of a Case With HRAS and PIK3CA Mutations by Next-Generation Sequencing. Int J Surg Pathol. 2018; 27(4):441-445. DOI: 10.1177/1066896918821182. View

Simpson R, Cope N, Skalova A, Michal M . Malignant adenomyoepithelioma of the breast with mixed osteogenic, spindle cell, and carcinomatous differentiation. Am J Surg Pathol. 1998; 22(5):631-6. DOI: 10.1097/00000478-199805000-00015. View

Awamleh A, Gudi M, Shousha S . Malignant adenomyoepithelioma of the breast with lymph node metastasis: a detailed immunohistochemical study. Case Rep Pathol. 2012; 2012:305858. PMC: 3420733. DOI: 10.1155/2012/305858. View

Jones M, Fletcher J . Malignant adenomyoepithelioma of the breast. Pathology. 2017; 49(3):322-325. DOI: 10.1016/j.pathol.2016.11.015. View

10.

Oka K, Sando N, Moriya T, Yatabe Y . Malignant adenomyoepithelioma of the breast with matrix production may be compatible with one variant form of matrix-producing carcinoma: a case report. Pathol Res Pract. 2007; 203(8):599-604. DOI: 10.1016/j.prp.2007.04.004. View

11.

Shah A, Venkatesan S, Katoch R, Jaiswal S, Gambhir R, Bhardwaj R . Epithelial-Myoepithelial Carcinoma Ex Pleomorphic Adenoma in Breast : An Exotic Rarity. Med J Armed Forces India. 2016; 67(1):74-6. PMC: 4920632. DOI: 10.1016/S0377-1237(11)80023-7. View

12.

Thway K, Bown N, Miah A, Turner R, Fisher C . Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors. Head Neck Pathol. 2014; 9(2):273-9. PMC: 4424215. DOI: 10.1007/s12105-014-0556-2. View

13.

Silveira H, Almeida L, Nonaka C, Alves P, Ribeiro-Silva A, Leon J . Myoepithelial carcinoma with rhabdoid features in the maxillary sinus: Immunohistochemical and in situ hybridization analysis of a rare case. Oral Oncol. 2019; 93:116-119. DOI: 10.1016/j.oraloncology.2019.04.015. View

14.

Ahmadi N, Negahban S, Aledavood A, Daneshbod K, Daneshbod Y . Malignant adenomyoepithelioma of the breast: a review. Breast J. 2015; 21(3):291-6. DOI: 10.1111/tbj.12390. View

15.

Kihara M, Yokomise H, Irie A, Kobayashi S, Kushida Y, Yamauchi A . Malignant adenomyoepithelioma of the breast with lung metastases: report of a case. Surg Today. 2002; 31(10):899-903. DOI: 10.1007/s005950170031. View

16.

Kiaer H, Nielsen B, Paulsen S, Sorensen I, Dyreborg U, Blichert-Toft M . Adenomyoepithelial adenosis and low-grade malignant adenomyoepithelioma of the breast. Virchows Arch A Pathol Anat Histopathol. 1984; 405(1):55-67. DOI: 10.1007/BF00694925. View

17.

Sugano I, Nagao T, Tajima Y, Ishida Y, Nagao K, Ooeda Y . Malignant adenomyoepithelioma of the breast: a non-tubular and matrix-producing variant. Pathol Int. 2001; 51(3):193-9. DOI: 10.1046/j.1440-1827.2001.01178.x. View

18.

Lubin D, Toorens E, Zhang P, Jaffer S, Baraban E, Bleiweiss I . Adenomyoepitheliomas of the Breast Frequently Harbor Recurrent Hotspot Mutations in PIK3-AKT Pathway-related Genes and a Subset Show Genetic Similarity to Salivary Gland Epithelial-Myoepithelial Carcinoma. Am J Surg Pathol. 2019; 43(7):1005-1013. DOI: 10.1097/PAS.0000000000001275. View

19.

Roberts C, Biegel J . The role of SMARCB1/INI1 in development of rhabdoid tumor. Cancer Biol Ther. 2009; 8(5):412-6. PMC: 2709499. DOI: 10.4161/cbt.8.5.8019. View

20.

Takahashi I , Tashiro , Wakasugi , Onohara , Nishizaki , Ishikawa . Malignant Adenomyoepithelioma of the Breast:A Case with Distant Metastases. Breast Cancer. 2000; 6(1):73-77. DOI: 10.1007/BF02966911. View