Evaluation of Sialyl-Lactotetra As a Marker for Epithelial Ovarian Tumors

Overview

Journal Front Oncol

Specialty Oncology

Date 2020 Oct 19

PMID 33072588

Citations 1

Authors

Angela Barone

Anna Linder

Constantina Mateoiu

Rasmus Koster Larsen

Ola Blixt

Susann Teneberg

Karin Sundfeldt

Affiliations

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Abstract

Ovarian carcinoma is a heterogeneous disease with distinct molecular and histological profiles, ranging from low grade atypia to highly aggressive tumors associated with a poor prognosis. In the present study, glycosphingolipids were isolated from human high-grade serous ovarian carcinoma, whereby the novel stem cell marker Sialyl-lactotetra (S-Lc) was characterized in two out of three cases. The presence and level of S-Lc was further evaluated immunohistochemically in a cohort of patients with ovarian tumors ranging from benign lesions to high grade serous carcinoma ( = 478). Its expression was assessed in association with tumor grade, stage, histology, and survival. The data showed that S-Lc is most common and highly expressed in borderline type tumors and carcinomas with low levels of aggressiveness, such as mucinous, endometrioid, and low grade serous. Accordingly, S-Lc-positivity was associated with better disease-free survival. The expression of S-Lc was seemingly associated with lineage continuity and could be traced from premalignant lesions to carcinoma, suggesting inheritance by a stem cell lineage that gives rise to generally indolent tumors.

Citing Articles

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PMID: 34741527 PMC: 9299683. DOI: 10.1002/ijc.33866.

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