Surface Marker Antigens in the Characterization of Human Embryonic Stem Cells

Overview

Journal Stem Cell Res

Publisher Elsevier

Specialty Cell Biology

Date 2009 Apr 29

PMID 19398226

Citations 40

Authors

Andrew J Wright

Peter W Andrews

Affiliations

Soon will be listed here.

Abstract

The use of cell surface antigens to characterise embryonic stem (ES) cells, and to monitor their differentiation, has had a long history, stretching back to the early studies of differentiation antigens in the haematopoietic system, and their application to teratocarcinomas and embryonal carcinoma (EC) cells in the laboratory mouse. A wide series of such antigens, which include both glycolipids and glycoproteins are now extensively used in studies of human ES cells. Many of these were first identified using both mouse and human EC cells, although the cell surface antigen phenotype of human EC and ES cells has proved to be significantly different from that of murine EC and ES cells.

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