Targeting the Epigenetic Addiction of Merkel Cell Carcinoma

Overview

Journal EMBO Mol Med

Specialty Molecular Biology

Date 2020 Oct 16

PMID 33063436

Citations 6

Authors

Federico Mauri

Cedric Blanpain

Affiliations

Soon will be listed here.

Abstract

Merkel cell carcinoma (MCC) is a rare but very aggressive neuroendocrine cancer of the skin, with very limited therapeutic options. Although immunotherapy is effective in some cases, there is an unmet need for new therapeutic approaches in MCCs. In this issue of EMBO Molecular Medicine, Leiendecker et al identify a selective vulnerability of MCC for inhibitors of the lysine-specific histone demethylase 1A (LSD1). LSD1 inhibitors promote differentiation of tumor cells toward normal Merkel cell fate, impairing tumor cell growth in vivo, and opening new avenues for the treatment of patients with MCC.

Citing Articles

Advancing Treatment Options for Merkel Cell Carcinoma: A Review of Tumor-Targeted Therapies.

Nammour H, Madrigal K, Starling C, Doan H Int J Mol Sci. 2024; 25(20).

PMID: 39456853 PMC: 11507330. DOI: 10.3390/ijms252011055.

The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma.

Mazziotta C, Lanzillotti C, Gafa R, Touze A, Durand M, Martini F Front Oncol. 2022; 12:832047.

PMID: 35350569 PMC: 8957841. DOI: 10.3389/fonc.2022.832047.

Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma.

Rotondo J, Mazziotta C, Lanzillotti C, Tognon M, Martini F Int J Mol Sci. 2021; 22(21).

PMID: 34768895 PMC: 8584046. DOI: 10.3390/ijms222111464.

Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis.

Soliman S, Orlacchio A, Verginelli F Microorganisms. 2021; 9(6).

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Merkel Cell Carcinoma: New Trends.

Zwijnenburg E, Lubeek S, Werner J, Amir A, Weijs W, Takes R Cancers (Basel). 2021; 13(7).

PMID: 33807446 PMC: 8036880. DOI: 10.3390/cancers13071614.

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