(Basil) Modulates Apoptosis and Neurogenesis in Olfactory Pulp of Mice Exposed to Chronic Unpredictable Mild Stress

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2020 Oct 16

PMID 33061923

Citations 4

Authors

Nasra N Ayuob

Maha J Balgoon

Soad Ali

Ibrahim S Alnoury

Hailah M Almohaimeed

Amany A AbdElfattah

Affiliations

Soon will be listed here.

Abstract

Background: ) was described to have antidepressant and anxiolytic activities. Although the relationship between the main olfactory bulb (MOB) and depression was recently reported, the chronic stress-induced dysfunction of the MOB is not clearly described.

Objectives: This study aimed to assess the efficacy of inhalation of essential oils in improving chronic unpredictable mild stress (CUMS)-induced changes in MOB of mice and understand the mechanism underlying such effect.

Materials And Methods: Adult male mice (n=40) were assigned into four groups included the control, CUMS-exposed, CUMS + fluoxetine (FLU), CUMS + . Behavioral changes, serum corticosterone level, and gene expression of GFAP, Ki 67, and caspase-3 were assessed using real-time PCR (RT-PCR). Histopathological and immunochemical examination of the MOB was performed.

Results: FLU and significantly down-regulated (p = 0.002, p<0.001) caspase-3 gene expression indicating reduced apoptosis and up-regulated (p = 0.002, p < 0.001) Ki67 gene expression indicating enhanced neurogenesis in MOB, respectively. FLU and -treated mice markedly improved MOB mitral cell layer distortion and shrinkage induced by CUMS.

Conclusion: relieved both biochemically and histopathological chronic stress-induced changes in the main olfactory bulb possibly through up-regulation of gene expression of GFAP and Ki67 and down-regulation of caspase-3 in the MOB.

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Musk () Attenuates Changes in Main Olfactory Bulb of Depressed Mice: Behavioral, Biochemical, and Histopathological Evidence.

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PMID: 34512285 PMC: 8430345. DOI: 10.3389/fnbeh.2021.704180.

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