Adult Olfactory Bulb Neurogenesis

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2016 May 29

PMID 27235474

Citations 73

Authors

Pierre-Marie Lledo

Matt Valley

Affiliations

Soon will be listed here.

Abstract

Most organisms use their olfactory system to detect and analyze chemical cues from the external world to guide essential behaviors. From worms to vertebrates, chemicals are detected by odorant receptors expressed by olfactory sensory neurons, which in vertebrates send an axon to the primary processing center called the olfactory bulb (OB). Within the OB, sensory neurons form excitatory synapses with projection neurons and with inhibitory interneurons. Thus, because of complex synaptic interactions, the output of a given projection neuron is determined not only by the sensory input, but also by the activity of local inhibitory interneurons that are regenerated throughout life in the process of adult neurogenesis. Herein, we discuss how it is optimized and why.

Citing Articles

Specific neuroblast-derived signals control both cell migration and fate in the rostral migratory stream.

Zhou W, Munoz J, Henry Ho H, Hanamura K, Dalva M bioRxiv. 2025; .

PMID: 40027825 PMC: 11870606. DOI: 10.1101/2025.02.18.638163.

scBSP: A fast and accurate tool for identifying spatially variable features from high-resolution spatial omics data.

Li J, Raina M, Wang Y, Xu C, Su L, Guo Q bioRxiv. 2025; .

PMID: 39974940 PMC: 11838397. DOI: 10.1101/2025.02.02.636138.

Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders.

Chen Y, Kostka J Front Neurosci. 2024; 18:1502779.

PMID: 39539496 PMC: 11557544. DOI: 10.3389/fnins.2024.1502779.

Olfactory bulb stimulation mitigates Alzheimer's-like disease progression.

Salimi M, Nazari M, Shahsavar P, Dehghan S, Javan M, Mirnajafi-Zadeh J CNS Neurosci Ther. 2024; 30(10):e70056.

PMID: 39404073 PMC: 11474698. DOI: 10.1111/cns.70056.

Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction.

Wang K, Liu X, Liu S, Wang X, Wei Y, Zhu J Theranostics. 2024; 14(11):4499-4518.

PMID: 39113792 PMC: 11303084. DOI: 10.7150/thno.96045.

References

Zupanc G . A comparative approach towards the understanding of adult neurogenesis. Brain Behav Evol. 2002; 58(5):246-9. DOI: 10.1159/000057568. View

Kunze W, Shafton A, Kem R, McKenzie J . Intracellular responses of olfactory bulb granule cells to stimulating the horizontal diagonal band nucleus. Neuroscience. 1992; 48(2):363-9. DOI: 10.1016/0306-4522(92)90496-o. View

Moreno M, Linster C, Escanilla O, Sacquet J, Didier A, Mandairon N . Olfactory perceptual learning requires adult neurogenesis. Proc Natl Acad Sci U S A. 2009; 106(42):17980-5. PMC: 2764902. DOI: 10.1073/pnas.0907063106. View

Curtis M, Low V, Faull R . Neurogenesis and progenitor cells in the adult human brain: a comparison between hippocampal and subventricular progenitor proliferation. Dev Neurobiol. 2012; 72(7):990-1005. DOI: 10.1002/dneu.22028. View

Corotto F, Henegar J, Maruniak J . Odor deprivation leads to reduced neurogenesis and reduced neuronal survival in the olfactory bulb of the adult mouse. Neuroscience. 1994; 61(4):739-44. DOI: 10.1016/0306-4522(94)90397-2. View

Kirschenbaum B, Doetsch F, Lois C, Alvarez-Buylla A . Adult subventricular zone neuronal precursors continue to proliferate and migrate in the absence of the olfactory bulb. J Neurosci. 1999; 19(6):2171-80. PMC: 6782582. View

Mouret A, Gheusi G, Gabellec M, de Chaumont F, Olivo-Marin J, Lledo P . Learning and survival of newly generated neurons: when time matters. J Neurosci. 2008; 28(45):11511-6. PMC: 6671302. DOI: 10.1523/JNEUROSCI.2954-08.2008. View

Breton-Provencher V, Lemasson M, Peralta 3rd M, Saghatelyan A . Interneurons produced in adulthood are required for the normal functioning of the olfactory bulb network and for the execution of selected olfactory behaviors. J Neurosci. 2009; 29(48):15245-57. PMC: 6665973. DOI: 10.1523/JNEUROSCI.3606-09.2009. View

Kay L, Stopfer M . Information processing in the olfactory systems of insects and vertebrates. Semin Cell Dev Biol. 2006; 17(4):433-42. DOI: 10.1016/j.semcdb.2006.04.012. View

10.

Lepousez G, Valley M, Lledo P . The impact of adult neurogenesis on olfactory bulb circuits and computations. Annu Rev Physiol. 2012; 75:339-63. DOI: 10.1146/annurev-physiol-030212-183731. View

11.

Hayes . To nest communally or not to nest communally: a review of rodent communal nesting and nursing. Anim Behav. 2000; 59(4):677-688. DOI: 10.1006/anbe.1999.1390. View

12.

Ming G, Song H . Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron. 2011; 70(4):687-702. PMC: 3106107. DOI: 10.1016/j.neuron.2011.05.001. View

13.

DeFelipe J, Lopez-Cruz P, Benavides-Piccione R, Bielza C, Larranaga P, Anderson S . New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci. 2013; 14(3):202-16. PMC: 3619199. DOI: 10.1038/nrn3444. View

14.

Livneh Y, Feinstein N, Klein M, Mizrahi A . Sensory input enhances synaptogenesis of adult-born neurons. J Neurosci. 2009; 29(1):86-97. PMC: 6664905. DOI: 10.1523/JNEUROSCI.4105-08.2009. View

15.

Lledo P, Lagier S . Adjusting neurophysiological computations in the adult olfactory bulb. Semin Cell Dev Biol. 2006; 17(4):443-53. DOI: 10.1016/j.semcdb.2006.04.011. View

16.

Mizrahi A, Katz L . Dendritic stability in the adult olfactory bulb. Nat Neurosci. 2003; 6(11):1201-7. DOI: 10.1038/nn1133. View

17.

Mandairon N, Jourdan F, Didier A . Deprivation of sensory inputs to the olfactory bulb up-regulates cell death and proliferation in the subventricular zone of adult mice. Neuroscience. 2003; 119(2):507-16. DOI: 10.1016/s0306-4522(03)00172-6. View

18.

Nissant A, Bardy C, Katagiri H, Murray K, Lledo P . Adult neurogenesis promotes synaptic plasticity in the olfactory bulb. Nat Neurosci. 2009; 12(6):728-30. DOI: 10.1038/nn.2298. View

19.

Petreanu L, Alvarez-Buylla A . Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction. J Neurosci. 2002; 22(14):6106-13. PMC: 6757952. DOI: 20026588. View

20.

Livneh Y, Mizrahi A . Experience-dependent plasticity of mature adult-born neurons. Nat Neurosci. 2011; 15(1):26-8. DOI: 10.1038/nn.2980. View