Thymoma Associated with Pure Red Cell Aplasia: a Case Report and Literature Review
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Pure red cell aplasia (PRCA) is a rare hematological complication associated with thymoma. Remission of PRCA occurs after thymectomy but can reappear after a latency period even without recurrence of thymoma. We report a case and we have reviewed the literature of thymoma associated with PRCA. Because of less number of reported cases, there have been no clinical trials investigating the immunosuppression regimen following thymectomy for thymoma associated with PRCA. After reviewing the literature, we came to a conclusion that thymectomy followed by immumosuppression with the cyclosporin-containing regimen is currently the most effective treatment.
Scilla F, Rupe C, Gioco G, Raffaelli L, Lococo F, Mazzarella C Heliyon. 2025; 11(2):e41931.
PMID: 39906813 PMC: 11791272. DOI: 10.1016/j.heliyon.2025.e41931.
A Clinical Case of Thymoma Presenting With Pure Erythroid Aplasia.
Ramoa Oliveira A, Camoes Neves J, Vasconcelos A, Rodrigues F Cureus. 2025; 17(1):e76750.
PMID: 39897222 PMC: 11785415. DOI: 10.7759/cureus.76750.
Thrombocytosis and megakaryocyte changes associated with PRCA.
Abdallah J, Williams R, Awada H, Raman G, Ozcan Y, Orland M Blood Adv. 2024; 8(12):3058-3062.
PMID: 38564765 PMC: 11215193. DOI: 10.1182/bloodadvances.2023012309.
Minimally invasive extended thymectomy for thymoma associated with pure red cell aplasia.
Wagh A, Bhagvat S, Bhandarwar A, Harivelam C, Ganesan B, Sawardekar V Indian J Thorac Cardiovasc Surg. 2022; 38(2):199-203.
PMID: 35221558 PMC: 8857358. DOI: 10.1007/s12055-021-01273-3.