Genetics of COVID-19

Overview

Journal J Pediatr (Rio J)

Specialty Pediatrics

Date 2020 Oct 15

PMID 33058776

Citations 13

Authors

Salmo Raskin

Affiliations

Soon will be listed here.

Abstract

Objective: This narrative, non-systematic review provides an update on the genetic aspects of the SARS-CoV-2 virus and its interactions with the human genome within the context of COVID-19. Although the main focus is on the etiology of this new disease, the genetics of SARS-CoV-2 impacts prevention, diagnosis, prognosis, and the development of therapies.

Data Source: A literature search was conducted on MEDLINE, BioRxiv, and SciELO, as well as a manual search on the internet (mainly in 2019 and 2020) using the keywords "COVID-19," "SARS-CoV-2," "coronavirus," "genetics," "molecular," "mutation," "vaccine," "Brazil," "Brasil," and combinations of these terms. The keywords "Brazil" and "Brasil" were used to find publications that were specific to the Brazilian population's molecular epidemiology data. Articles most relevant to the scope were selected non-systematically.

Data Synthesis: A number of publications illustrate an expanding knowledge on the genetics and genomics of SARS-CoV-2 and its implications for understanding COVID-19.

Conclusions: Knowledge of the SARS-CoV-2 genome sequence permits an in-depth investigation of the role its proteins play in the pathophysiology of COVID-19, which in turn will be enormously valuable for understanding the evolutionary, clinical, and epidemiological aspects of this disease and focusing on prevention and treatment.

Citing Articles

SARS-CoV-2 Resistance to Small Molecule Inhibitors.

Lopez U, Hasan M, Havranek B, Islam S Curr Clin Microbiol Rep. 2024; 11(3):127-139.

PMID: 39559548 PMC: 11573241. DOI: 10.1007/s40588-024-00229-6.

Equal Maintenance of Anti-SARS-CoV-2 Antibody Levels Induced by Heterologous and Homologous Regimens of the BNT162b2, ChAdOx1, CoronaVac and Ad26.COV2.S Vaccines: A Longitudinal Study Up to the 4th Dose of Booster.

do Nascimento T, Nogami P, de Oliveira C, Neto W, da Silva C, Ribeiro A Vaccines (Basel). 2024; 12(7).

PMID: 39066430 PMC: 11281708. DOI: 10.3390/vaccines12070792.

Association of vaccination status and severity of SARS-CoV-2 infections in hospitalized patients.

Guerrero D, Baker T, Corn M, Keup S, Nickell A, Cao L Vaccine X. 2024; 18:100473.

PMID: 38545562 PMC: 10966303. DOI: 10.1016/j.jvacx.2024.100473.

Repurposing the in-house generated Alzheimer's disease targeting molecules through computational and preliminary in-vitro studies for the management of SARS-coronavirus-2.

Singh G, Thomas J, Wadhawa S, Kashyap A, Rahaman S, Borkotoky S Mol Divers. 2023; 28(5):2847-2862.

PMID: 37749454 DOI: 10.1007/s11030-023-10717-4.

A Machine Learning Approach to Identify Potential miRNA-Gene Regulatory Network Contributing to the Pathogenesis of SARS-CoV-2 Infection.

Das R, Sinnarasan V, Paul D, Venkatesan A Biochem Genet. 2023; 62(2):987-1006.

PMID: 37515735 DOI: 10.1007/s10528-023-10458-x.

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