Genomic and Phylogenetic Characterisation of an Imported Case of SARS-CoV-2 in Amazonas State, Brazil

Overview

Journal Mem Inst Oswaldo Cruz

Specialties Parasitology
Tropical Medicine

Date 2020 Sep 30

PMID 32997001

Citations 31

Authors

Valdinete Alves do Nascimento

Andre de Lima Guerra Corado

Fernanda Oliveira do Nascimento

Agatha Kelly Araujo da Costa

Debora Camila Gomes Duarte

Sergio Luiz Bessa Luz

Luciana Mara Fe Goncalves

Michele Silva de Jesus

Cristiano Fernandes da Costa

Edson Delatorre

Felipe Gomes Naveca

Affiliations

Soon will be listed here.

Abstract

A new coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] is currently causing a life-threatening pandemic. In this study, we report the complete genome sequencing and genetic characterisation of a SARS-CoV-2 detected in Manaus, Amazonas, Brazil, and the protocol we designed to generate high-quality SARS-CoV-2 full genome data. The isolate was obtained from an asymptomatic carrier returning from Madrid, Spain. Nucleotide sequence analysis showed a total of nine mutations in comparison with the original human case in Wuhan, China, and support this case as belonging to the recently proposed lineage A.2. Phylogeographic analysis further confirmed the likely European origin of this case. To our knowledge, this is the first SARS-CoV-2 genome obtained from the North Brazilian Region. We believe that the information generated in this study may contribute to the ongoing efforts toward the SARS-CoV-2 emergence.

Citing Articles

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Naveca F, Nascimento V, Nascimento F, Ogrzewalska M, Pauvolid-Correa A, Araujo M Sci Rep. 2023; 13(1):7306.

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