Impact of Treatment Delay on Survival of Oral/oropharyngeal Cancers: Results of a Nationwide Screening Program

Overview

Journal Head Neck

Specialties General Surgery
Oncology

Date 2020 Oct 13

PMID 33047420

Citations 6

Authors

William Wang-Yu Su

Yi-Huah Lee

Amy Ming-Fang Yen

Sam Li-Sheng Chen

Chen-Yang Hsu

Sherry Yueh-Hsia Chiu

Jean Ching-Yuan Fann

Yi-Chia Lee

Han-Mo Chiu

Shu-Chun Hsiao

Tsui-Hsia Hsu

Hsiu-Hsi Chen

Affiliations

Soon will be listed here.

Abstract

Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC).

Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012.

Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P < .05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital.

Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.

Citing Articles

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