Unveiling the Reaction Process of the Amine in Direct Amidation of Aromatic Ketones in HO

Overview

Journal ChemistryOpen

Specialty Chemistry

Date 2020 Oct 12

PMID 33042727

Citations 1

Authors

Fangjun He

Rumeng Qu

Jie Su

Muyao Du

Junqiang Liu

Yiping Chen

Bo Wang

Affiliations

Soon will be listed here.

Abstract

In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for a long time. In this work, we disclosed that the amine acts as both reactant and catalyst. Specifically, the determination of reaction intermediates revealed the full mechanism, based on which, the introduction of one equivalent base in the amidation is showcased here that a high yield (∼95 %) can be afforded using only 1.1 equiv. of amine.

Citing Articles

Unveiling the reaction process of the amine in direct amidation of aromatic ketones in HO.

He F, Qu R, Su J, Du M, Liu J, Chen Y ChemistryOpen. 2020; 9(10):996-1000.

PMID: 33042727 PMC: 7539465. DOI: 10.1002/open.202000178.

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