The Functional Medicine Approach to COVID-19: Nutrition and Lifestyle Practices for Strengthening Host Defense

Overview

Journal Integr Med (Encinitas)

Specialty Rehabilitation Medicine

Date 2020 Oct 12

PMID 33041708

Citations 2

Authors

D M Minich

P J Hanaway

Affiliations

Soon will be listed here.

Abstract

The developing symptoms of COVID-19, as well as the progression of illness and fatality, are a clearly a function of the overall health status of the individual. Complex, chronic diseases such as obesity, hypertension, and diabetes are directly correlated with risk of disease severity and mortality. We explore lifestyle interventions that have specifically been demonstrated to strengthen host defense, reduce the probability and mitigate the severity of viral infection. Lifestyle interventions, from a Functional Medicine perspective, include nutrition, sleep, exercise, stress reduction, and connection. These factors, when in balance, provide a foundation for optimal health and immune function.

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References

Simpson R, Campbell J, Gleeson M, Kruger K, Nieman D, Pyne D . Can exercise affect immune function to increase susceptibility to infection?. Exerc Immunol Rev. 2020; 26:8-22. View

Cotillard A, Kennedy S, Kong L, Prifti E, Pons N, Le Chatelier E . Dietary intervention impact on gut microbial gene richness. Nature. 2013; 500(7464):585-8. DOI: 10.1038/nature12480. View

Marshall Jr G . The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases. Immunol Allergy Clin North Am. 2010; 31(1):133-40. PMC: 2991159. DOI: 10.1016/j.iac.2010.09.013. View

Venter C, Eyerich S, Sarin T, Klatt K . Nutrition and the Immune System: A Complicated Tango. Nutrients. 2020; 12(3). PMC: 7146186. DOI: 10.3390/nu12030818. View

Agarwal S, Marshall Jr G . Stress effects on immunity and its application to clinical immunology. Clin Exp Allergy. 2001; 31(1):25-31. View

Simopoulos A . Omega-3 fatty acids and athletics. Curr Sports Med Rep. 2007; 6(4):230-6. View

Segerstrom S, Miller G . Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004; 130(4):601-30. PMC: 1361287. DOI: 10.1037/0033-2909.130.4.601. View

Heiman M, Greenway F . A healthy gastrointestinal microbiome is dependent on dietary diversity. Mol Metab. 2016; 5(5):317-320. PMC: 4837298. DOI: 10.1016/j.molmet.2016.02.005. View

Belenky G, Wesensten N, Thorne D, Thomas M, Sing H, Redmond D . Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study. J Sleep Res. 2003; 12(1):1-12. DOI: 10.1046/j.1365-2869.2003.00337.x. View

10.

Lopez-Garcia E, Schulze M, Meigs J, Manson J, Rifai N, Stampfer M . Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J Nutr. 2005; 135(3):562-6. DOI: 10.1093/jn/135.3.562. View

11.

Li Q, Li P, Garcia G, Johnson R, Feng L . Genomic profiling of neutrophil transcripts in Asian Qigong practitioners: a pilot study in gene regulation by mind-body interaction. J Altern Complement Med. 2005; 11(1):29-39. DOI: 10.1089/acm.2005.11.29. View

12.

Barrett B, Hayney M, Muller D, Rakel D, Ward A, Obasi C . Meditation or exercise for preventing acute respiratory infection: a randomized controlled trial. Ann Fam Med. 2012; 10(4):337-46. PMC: 3392293. DOI: 10.1370/afm.1376. View

13.

Birlouez-Aragon I, Saavedra G, Tessier F, Galinier A, Ait-Ameur L, Lacoste F . A diet based on high-heat-treated foods promotes risk factors for diabetes mellitus and cardiovascular diseases. Am J Clin Nutr. 2010; 91(5):1220-6. DOI: 10.3945/ajcn.2009.28737. View

14.

Inagaki T, Muscatell K, Irwin M, Cole S, Eisenberger N . Inflammation selectively enhances amygdala activity to socially threatening images. Neuroimage. 2011; 59(4):3222-6. PMC: 3348143. DOI: 10.1016/j.neuroimage.2011.10.090. View

15.

Eisenberger N, Moieni M, Inagaki T, Muscatell K, Irwin M . In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior. Neuropsychopharmacology. 2016; 42(1):242-253. PMC: 5143485. DOI: 10.1038/npp.2016.141. View

16.

FANG I, Tooley D, Gatewood C, Renegar K, Majde J, Krueger J . Differential effects of total and upper airway influenza viral infection on sleep in mice. Sleep. 1996; 19(4):337-42. View

17.

Nishitani N, Sakakibara H . Subjective poor sleep and white blood cell count in male Japanese workers. Ind Health. 2007; 45(2):296-300. DOI: 10.2486/indhealth.45.296. View

18.

Chen P, Mao L, Nassis G, Harmer P, Ainsworth B, Li F . Coronavirus disease (COVID-19): The need to maintain regular physical activity while taking precautions. J Sport Health Sci. 2020; 9(2):103-104. PMC: 7031771. DOI: 10.1016/j.jshs.2020.02.001. View

19.

Dimitrov S, Hulteng E, Hong S . Inflammation and exercise: Inhibition of monocytic intracellular TNF production by acute exercise via β-adrenergic activation. Brain Behav Immun. 2016; 61:60-68. PMC: 6555138. DOI: 10.1016/j.bbi.2016.12.017. View

20.

Falkenberg R, Eising C, Peters M . Yoga and immune system functioning: a systematic review of randomized controlled trials. J Behav Med. 2018; 41(4):467-482. DOI: 10.1007/s10865-018-9914-y. View