The Adverse Effects of Psychological Stress on Immunoregulatory Balance: Applications to Human Inflammatory Diseases

Overview

Journal Immunol Allergy Clin North Am

Specialty Allergy & Immunology

Date 2010 Nov 25

PMID 21094928

Citations 34

Authors

Gailen D Marshall Jr

Affiliations

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Abstract

Psychological stress has known effects on the immune system, including impacting effector and regulatory components. This can result in increased susceptibility to various infections, latent virus reactivation, and impact on immunoregulatory circuits. One of the great challenges in translational research is defining the risks associated with stress in specific patient populations and individuals. Future studies must include identification and validation of biomarkers that can categorize patient risk for adverse immune effects from various forms and degrees of psychological stress and how this impacts the course of their inflammatory disease.

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