Progenitor Cell Therapy for Acquired Pediatric Nervous System Injury: Traumatic Brain Injury and Acquired Sensorineural Hearing Loss

Overview

Journal Stem Cells Transl Med

Publisher Oxford University Press

Specialties Cell Biology
Pharmacology

Date 2020 Oct 9

PMID 33034162

Citations 5

Authors

James E Baumgartner

Linda S Baumgartner

Michael E Baumgartner

Ernest J Moore

Steven A Messina

Michael D Seidman

David R Shook

Affiliations

Soon will be listed here.

Abstract

While cell therapies hold remarkable promise for replacing injured cells and repairing damaged tissues, cell replacement is not the only means by which these therapies can achieve therapeutic effect. For example, recent publications show that treatment with varieties of adult, multipotent stem cells can improve outcomes in patients with neurological conditions such as traumatic brain injury and hearing loss without directly replacing damaged or lost cells. As the immune system plays a central role in injury response and tissue repair, we here suggest that multipotent stem cell therapies achieve therapeutic effect by altering the immune response to injury, thereby limiting damage due to inflammation and possibly promoting repair. These findings argue for a broader understanding of the mechanisms by which cell therapies can benefit patients.

Citing Articles

Research progress on the treatment and nursing of sensorineural hearing loss.

Liu F, Han B, Zhou X, Huang S, Huang J Front Neurosci. 2023; 17:1199946.

PMID: 37346087 PMC: 10279882. DOI: 10.3389/fnins.2023.1199946.

Mitochondrial redox system: A key target of antioxidant therapy to prevent acquired sensorineural hearing loss.

Baek J, Kim Y, Lee K, Kim U Front Pharmacol. 2023; 14:1176881.

PMID: 37063286 PMC: 10102650. DOI: 10.3389/fphar.2023.1176881.

Traumatic brain injuries in children during COVID-19 pandemic: a national report from northern Iran.

Reihanian Z, Noori Roodsari N, Rimaz S, Asadi P, Khoshsima N, Rafiee Zadeh A Int J Burns Trauma. 2022; 12(4):175-179.

PMID: 36160672 PMC: 9490154.

The audiogram: Detection of pure-tone stimuli in ototoxicity monitoring and assessments of investigational medicines for the inner ear.

Le Prell C, Brewer C, Campbell K J Acoust Soc Am. 2022; 152(1):470.

PMID: 35931504 PMC: 9288270. DOI: 10.1121/10.0011739.

Progenitor cell therapy for acquired pediatric nervous system injury: Traumatic brain injury and acquired sensorineural hearing loss.

Baumgartner J, Baumgartner L, Baumgartner M, Moore E, Messina S, Seidman M Stem Cells Transl Med. 2020; 10(2):164-180.

PMID: 33034162 PMC: 7848325. DOI: 10.1002/sctm.20-0026.

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