Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Oct 7

PMID 33022980

Citations 3

Authors

Joan J Soldevila-Barreda

Kehinde B Fawibe

Maria Azmanova

Laia Rafols

Anais Pitto-Barry

Uche B Eke

Nicolas P E Barry

Affiliations

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Abstract

The synthesis, characterisation and evaluation of the in vitro cytotoxicity of four indole-based half-sandwich metal complexes towards two ovarian cancer cell lines (A2780 and A2780cisR) and one normal prostate cell line (PNT2) are presented herein. Although capable of inducing catalytic oxidation of NADH and able to reduce NAD with high turnover frequencies, in cells and in the presence of sodium formate, these complexes also strongly interact with biomolecules such as glutathione. This work highlights that efficient out-of-cells catalytic activity might lead to higher reactivity towards biomolecules, thus inhibiting the in-cells catalytic processes.

Citing Articles

Indole-Containing Metal Complexes and Their Medicinal Applications.

Kazemi Z, Rudbari H, Moini N, Momenbeik F, Carnamucio F, Micale N Molecules. 2024; 29(2).

PMID: 38257397 PMC: 10819683. DOI: 10.3390/molecules29020484.

Anticancer Water-Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation.

Azmanova M, Rafols L, Cooper P, Seaton C, Shnyder S, Pitto-Barry A Chembiochem. 2022; 23(18):e202200259.

PMID: 35838006 PMC: 9545474. DOI: 10.1002/cbic.202200259.

Indole-containing arene-ruthenium complexes with broad spectrum activity against antibiotic-resistant bacteria.

Nolan V, Rafols L, Harrison J, Soldevila-Barreda J, Crosatti M, Garton N Curr Res Microb Sci. 2022; 3:100099.

PMID: 35059676 PMC: 8760505. DOI: 10.1016/j.crmicr.2021.100099.

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