A Dinuclear Persulfide-Bridged Ruthenium Compound is a Hypoxia-Selective Hydrogen Sulfide (H S) Donor

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2020 Oct 6

PMID 33022823

Citations 7

Authors

Joshua J Woods

Justin J Wilson

Affiliations

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Abstract

Hydrogen sulfide (H S) is a gaseous molecule that has received attention for its role in biological processes and therapeutic potential in diseases, such as ischemic reperfusion injury. Despite its clinical relevance, delivery of H S to biological systems is hampered by its toxicity at high concentrations. Herein, we report the first metal-based H S donor that delivers this gas selectively to hypoxic cells. We further show that H S release from this compound protects H9c2 rat cardiomyoblasts from an in vitro model of ischemic reperfusion injury. These results validate the utility of redox-activated metal complexes as hypoxia-selective H S-releasing agents for use as tools to study the role of this gaseous molecule in complex biological systems.

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