Activity of Tigecycline or Colistin in Combination with Zidovudine Against Escherichia Coli Harboring (X) and

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2020 Oct 6

PMID 33020156

Citations 8

Authors

Yu-Feng Zhou

Ping Liu

Shu-He Dai

Jian Sun

Ya-Hong Liu

Xiao-Ping Liao

Affiliations

Soon will be listed here.

Abstract

Alternative therapeutic options are urgently needed against multidrug-resistant infections, especially in situations of preexisting tigecycline and colistin resistance. Here, we investigated synergistic activity of the antiretroviral drug zidovudine in combination with tigecycline or colistin against harboring (X) and and in a murine thigh infection model. Zidovudine and tigecycline/colistin combinations achieved synergistic killing and significantly decreased bacterial burdens by >2.5-log CFU/g in thigh tissues compared to each monotherapy.

Citing Articles

Overcoming (X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.

Liu J, Zheng S, Wu J, Zheng M, Cai D, Zhang Y Front Microbiol. 2025; 15:1502558.

PMID: 39764451 PMC: 11701230. DOI: 10.3389/fmicb.2024.1502558.

Restoring Colistin Sensitivity in Multidrug-Resistant Pathogenic Using Cinacalcet Hydrochloride.

Wang C, Zhang Z, Liu D, Li X, Zhang Z, Zeng Y Int J Mol Sci. 2024; 25(21).

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Zidovudine in synergistic combination with nitrofurantoin or omadacycline: and in murine urinary tract or lung infection evaluation against multidrug-resistant .

Tian P, Li Q, Guo M, Zhu Y, Zhu R, Guo Y Antimicrob Agents Chemother. 2024; 68(10):e0034424.

PMID: 39194261 PMC: 11459972. DOI: 10.1128/aac.00344-24.

Synergistic Effects of Capric Acid and Colistin against Colistin-Susceptible and Colistin-Resistant .

Liu Y, Qin Z, Yue H, Bergen P, Deng L, He W Antibiotics (Basel). 2023; 12(1).

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