Juvenile-Onset Recurrent Respiratory Papillomatosis Aggressiveness: In Situ Study of the Level of Transcription of HPV E6 and E7

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2020 Oct 6

PMID 33019611

Citations 8

Authors

Charles Lepine

Thibault Voron

Dominique Berrebi

Marion Mandavit

Marine Nervo

Sophie Outh-Gauer

Helene Pere

Louis Tournier

Natacha Teissier

Eric Tartour

Nicolas Leboulanger

Louise Galmiche

Cecile Badoual

Affiliations

Soon will be listed here.

Abstract

Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is a condition related to HPV 6 and 11 infection which is characterized by the repeated growth of benign exophytic papilloma in the respiratory tract. Disease progression is unpredictable: some children experience minor symptoms, while others require multiple interventions due to florid growth. The aim of this study was to explore the biomarkers of JoRRP severity on a bicentric cohort of forty-eight children. We performed a CISH on the most recent sample of papilloma with a probe targeting the mRNA of the and genes of HPV 6 and 11 and an immunostaining with p16 antibody. For each patient HPV RNA CISH staining was assessed semi-quantitatively to define two scores: 1+, defined as a low staining extent, and 2+, defined as a high staining extent. This series contained 19 patients with a score of 1+ and 29 with a score of 2+. Patients with a score of 2+ had a median of surgical excision (SE) per year that was twice that of patients with a score of 1+ (respectively 6.1 versus 2.8, = 0.036). We found similar results with the median number of SE the first year. Regarding p16, all patients were negative. To conclude, HPV RNA CISH might be a biomarker which is predictive of disease aggressiveness in JoRRP, and might help in patient care management.

Citing Articles

"A systematic literature review of the epidemiology, clinical, economic and humanistic burden in recurrent respiratory papillomatosis".

Ovcinnikova O, Engelbrecht K, Verma M, Pandey R, Morais E Respir Res. 2024; 25(1):430.

PMID: 39696284 PMC: 11656596. DOI: 10.1186/s12931-024-03057-w.

Laryngeal Suction tube: A Novel Technique for Tracheal Ventilation in an Obstructed Airway in a Child with Respiratory Papillomatosis.

Saniasiaya J, Lim S, Kulasegarah J Indian J Otolaryngol Head Neck Surg. 2023; 75(2):1274-1276.

PMID: 37276073 PMC: 10234954. DOI: 10.1007/s12070-022-03411-8.

Molecular Mechanisms of Carcinogenesis in Pediatric Airways Tumors.

Soloperto D, Gazzini S, Cerullo R Int J Mol Sci. 2023; 24(3).

PMID: 36768522 PMC: 9916405. DOI: 10.3390/ijms24032195.

Human Papillomavirus Infection during Pregnancy and Childhood: A Comprehensive Review.

Ardekani A, Taherifard E, Mollalo A, Hemadi E, Roshanshad A, Fereidooni R Microorganisms. 2022; 10(10).

PMID: 36296208 PMC: 9607260. DOI: 10.3390/microorganisms10101932.

Expanded Basal Compartment and Disrupted Barrier in Vocal Fold Epithelium Infected with Mouse Papillomavirus MmuPV1.

King R, Ward-Shaw E, Hu R, Lambert P, Thibeault S Viruses. 2022; 14(5).

PMID: 35632798 PMC: 9146965. DOI: 10.3390/v14051059.

References

Rogers D, Ojha S, Maurer R, Hartnick C . Use of adjuvant intralesional bevacizumab for aggressive respiratory papillomatosis in children. JAMA Otolaryngol Head Neck Surg. 2013; 139(5):496-501. DOI: 10.1001/jamaoto.2013.1810. View

Naiman A, Ayari S, Nicollas R, Landry G, Colombeau B, Froehlich P . Intermediate-term and long-term results after treatment by cidofovir and excision in juvenile laryngeal papillomatosis. Ann Otol Rhinol Laryngol. 2006; 115(9):667-72. DOI: 10.1177/000348940611500903. View

Derkay C, Malis D, Zalzal G, Wiatrak B, KASHIMA H, Coltrera M . A staging system for assessing severity of disease and response to therapy in recurrent respiratory papillomatosis. Laryngoscope. 1998; 108(6):935-7. DOI: 10.1097/00005537-199806000-00026. View

Rosenberg T, Philipsen B, Mehlum C, Dyrvig A, Wehberg S, Chirila M . Therapeutic Use of the Human Papillomavirus Vaccine on Recurrent Respiratory Papillomatosis: A Systematic Review and Meta-Analysis. J Infect Dis. 2018; 219(7):1016-1025. DOI: 10.1093/infdis/jiy616. View

Donne A, Hampson L, Homer J, Hampson I . The role of HPV type in Recurrent Respiratory Papillomatosis. Int J Pediatr Otorhinolaryngol. 2009; 74(1):7-14. DOI: 10.1016/j.ijporl.2009.09.004. View

Campisi P, Hawkes M, Simpson K . The epidemiology of juvenile onset recurrent respiratory papillomatosis derived from a population level national database. Laryngoscope. 2010; 120(6):1233-45. DOI: 10.1002/lary.20901. View

Bonagura V, Hatam L, Rosenthal D, de Voti J, Lam F, Steinberg B . Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and -11. APMIS. 2010; 118(6-7):455-70. PMC: 2909665. DOI: 10.1111/j.1600-0463.2010.02617.x. View

Outh-Gauer S, Augustin J, Mandavit M, Grard O, Denize T, Nervo M . Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis. J Vis Exp. 2019; (148). DOI: 10.3791/59422. View

Go C, Schwartz M, Donovan D . Molecular transformation of recurrent respiratory papillomatosis: viral typing and p53 overexpression. Ann Otol Rhinol Laryngol. 2003; 112(4):298-302. DOI: 10.1177/000348940311200402. View

10.

Silverberg M, Thorsen P, Lindeberg H, Grant L, Shah K . Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis. Obstet Gynecol. 2003; 101(4):645-52. DOI: 10.1016/s0029-7844(02)03081-8. View

11.

Kreimer A, Clifford G, Boyle P, Franceschi S . Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev. 2005; 14(2):467-75. DOI: 10.1158/1055-9965.EPI-04-0551. View

12.

Best S, Mohr M, Zur K . Systemic bevacizumab for recurrent respiratory papillomatosis: A national survey. Laryngoscope. 2017; 127(10):2225-2229. PMC: 5607082. DOI: 10.1002/lary.26662. View

13.

Creelan B, Ahmad M, Kaszuba F, Khalil F, Welsh A, Ozdemirli M . Clinical Activity of Nivolumab for Human Papilloma Virus-Related Juvenile-Onset Recurrent Respiratory Papillomatosis. Oncologist. 2019; 24(6):829-835. PMC: 6656512. DOI: 10.1634/theoncologist.2018-0505. View

14.

Matsuzaki H, Makiyama K, Hirai R, Suzuki H, Asai R, Oshima T . Multi-Year Effect of Human Papillomavirus Vaccination on Recurrent Respiratory Papillomatosis. Laryngoscope. 2019; 130(2):442-447. DOI: 10.1002/lary.27993. View

15.

Gelder C, Williams O, Hart K, Wall S, Williams G, Ingrams D . HLA class II polymorphisms and susceptibility to recurrent respiratory papillomatosis. J Virol. 2003; 77(3):1927-39. PMC: 140867. DOI: 10.1128/jvi.77.3.1927-1939.2003. View

16.

Wiatrak B, Wiatrak D, Broker T, Lewis L . Recurrent respiratory papillomatosis: a longitudinal study comparing severity associated with human papilloma viral types 6 and 11 and other risk factors in a large pediatric population. Laryngoscope. 2004; 114(11 Pt 2 Suppl 104):1-23. DOI: 10.1097/01.mlg.000148224.83491.0f. View

17.

Allen C, Lee S, Norberg S, Kovalovsky D, Ye H, Clavijo P . Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis. J Immunother Cancer. 2019; 7(1):119. PMC: 6500000. DOI: 10.1186/s40425-019-0603-3. View

18.

Marsico M, Mehta V, Chastek B, Liaw K, Derkay C . Estimating the incidence and prevalence of juvenile-onset recurrent respiratory papillomatosis in publicly and privately insured claims databases in the United States. Sex Transm Dis. 2014; 41(5):300-5. DOI: 10.1097/OLQ.0000000000000115. View

19.

Kazlouskaya V, Shustef E, Allam S, Lal K, Elston D . Expression of p16 protein in lesional and perilesional condyloma acuminata and bowenoid papulosis: clinical significance and diagnostic implications. J Am Acad Dermatol. 2013; 69(3):444-9. DOI: 10.1016/j.jaad.2013.04.036. View

20.

Lawlor C, Balakrishnan K, Bottero S, Boudewyns A, Campisi P, Carter J . International Pediatric Otolaryngology Group (IPOG): Juvenile-onset recurrent respiratory papillomatosis consensus recommendations. Int J Pediatr Otorhinolaryngol. 2019; 128:109697. DOI: 10.1016/j.ijporl.2019.109697. View