Molecular Mechanisms of Carcinogenesis in Pediatric Airways Tumors

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Feb 11

PMID 36768522

Authors

Davide Soloperto

Sandra Gazzini

Raffaele Cerullo

Affiliations

Soon will be listed here.

Abstract

Primary tumors of the airways in the pediatric population are very rare entities. For this reason, little is known about the pathogenesis of these neoplasms. Understanding the biology has different practical implications: for example, it could help in the differential diagnosis, have a prognostic significance, or may lead to the development of a targeted therapy. The aim of this article is to present the current knowledge about pediatric airways tumors, focusing on the molecular mechanisms that cause the onset and progression of these neoplasms. After a brief introduction of epidemiology and clinical presentation, the tumorigenesis of the most frequent pediatric airways tumors will be described: Juvenile-onset recurrent respiratory papillomatosis (JORRP), Subglottic Hemangiona (SH), Rhabdomyosarcoma (RMS), and Mucoepidermoid carcinoma (MEC).

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References

Kapels K, Nishio J, Zhou M, Qualman S, Bridge J . Embryonal rhabdomyosarcoma with a der(16)t(1;16) translocation. Cancer Genet Cytogenet. 2007; 174(1):68-73. DOI: 10.1016/j.cancergencyto.2006.11.013. View

Poli E, Zin A, Cattelan M, Tombolan L, Zanetti I, Scagnellato A . Prognostic Value of Circulating IGFBP2 and Related Autoantibodies in Children with Metastatic Rhabdomyosarcomas. Diagnostics (Basel). 2020; 10(2). PMC: 7168276. DOI: 10.3390/diagnostics10020115. View

Hancock B, Di Lorenzo M, Youssef S, Yazbeck S, Marcotte J, COLLIN P . Childhood primary pulmonary neoplasms. J Pediatr Surg. 1993; 28(9):1133-6. DOI: 10.1016/0022-3468(93)90147-d. View

Xiao Y, Wu X, Ma L, Gui J, Bai L, Ni X . Enhanced T2-like peripheral adaptive immune responses in Juvenile-onset Recurrent Respiratory Papillomatosis (JORRP). Immunol Lett. 2017; 191:31-34. DOI: 10.1016/j.imlet.2017.08.026. View

Itinteang T, Withers A, Davis P, Tan S . Biology of infantile hemangioma. Front Surg. 2015; 1:38. PMC: 4286974. DOI: 10.3389/fsurg.2014.00038. View

McCormick A, Tarchichi T, Azbell C, Grunwaldt L, Jabbour N . Subglottic hemangioma: Understanding the association with facial segmental hemangioma in a beard distribution. Int J Pediatr Otorhinolaryngol. 2018; 113:34-37. DOI: 10.1016/j.ijporl.2018.07.019. View

Jaramillo S, Rojas Y, Slater B, Baker M, Hicks M, Muscal J . Childhood and adolescent tracheobronchial mucoepidermoid carcinoma (MEC): a case-series and review of the literature. Pediatr Surg Int. 2016; 32(4):417-24. DOI: 10.1007/s00383-015-3849-y. View

Uihlein L, Liang M, Mulliken J . Pathogenesis of infantile hemangiomas. Pediatr Ann. 2012; 41(8):1-6. DOI: 10.3928/00904481-20120727-08. View

Doyle D, Gianoli G, Espinola T, Miller R . Recurrent respiratory papillomatosis: juvenile versus adult forms. Laryngoscope. 1994; 104(5 Pt 1):523-7. DOI: 10.1002/lary.5541040503. View

10.

Zhou C, Tuong Z, Frazer I . Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System. Front Oncol. 2019; 9:682. PMC: 6688195. DOI: 10.3389/fonc.2019.00682. View

11.

Chen J, Li J, Chen Z, Griffin J, Wu L . Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells. BMC Cancer. 2015; 15:803. PMC: 4624166. DOI: 10.1186/s12885-015-1827-3. View

12.

Hardison S, Wan W, Dodson K . The use of propranolol in the treatment of subglottic hemangiomas: A literature review and meta-analysis. Int J Pediatr Otorhinolaryngol. 2016; 90:175-180. DOI: 10.1016/j.ijporl.2016.09.012. View

13.

LAmoreaux W, Fitzgerald M, Reiner A, Hasty K, Charles S . Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro. Microvasc Res. 1998; 55(1):29-42. DOI: 10.1006/mvre.1997.2056. View

14.

Sherrington C, Sim D, Freezer N, Robertson C . Subglottic haemangioma. Arch Dis Child. 1997; 76(5):458-9. PMC: 1717188. DOI: 10.1136/adc.76.5.458. View

15.

Bethune G, Bethune D, Ridgway N, Xu Z . Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update. J Thorac Dis. 2012; 2(1):48-51. PMC: 3256436. View

16.

Yu Y, Fu L, Wang S, Jin Y, Han S, Chu P . Investigation of IGF2, IGFBP2 and p63 proteins in rhabdomyosarcoma tumors. Growth Horm IGF Res. 2017; 33:17-22. DOI: 10.1016/j.ghir.2017.01.002. View

17.

Serra A, Schackert H, Mohr B, Weise A, Liehr T, Fitze G . t(11;19)(q21;p12~p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma. J Pediatr Surg. 2007; 42(7):E23-9. DOI: 10.1016/j.jpedsurg.2007.04.031. View

18.

Kocjan B, Gale N, Boltezar I, Seme K, Fujs Komlos K, Hosnjak L . Identical human papillomavirus (HPV) genomic variants persist in recurrent respiratory papillomatosis for up to 22 years. J Infect Dis. 2012; 207(4):583-7. DOI: 10.1093/infdis/jis733. View

19.

Moriconi A, Cesta M, Cervellera M, Aramini A, Coniglio S, Colagioia S . Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007; 50(17):3984-4002. DOI: 10.1021/jm061469t. View

20.

Bauman N, Smith R . Recurrent respiratory papillomatosis. Pediatr Clin North Am. 1996; 43(6):1385-401. DOI: 10.1016/s0031-3955(05)70524-1. View